PMID: 9430201Jul 1, 1997Paper

Complement classical pathway expression by human skeletal myoblasts in vitro

Molecular Immunology
J LegoedecM Fontaine

Abstract

Human myoblasts express immunological properties in vitro and we have previously reported that they produce Complement (C) components of the alternative pathway. Myoblasts activate the classical pathway but are fully protected against C attack by the expression of major C regulators. In order to fully understand the relationship between myoblasts and C, we here report the biosynthesis of C components of the classical pathway by skeletal muscle cells. Human myoblasts in vitro produced C1q, C1r, C1s, C2 and C4 constitutively and all syntheses were upregulated after stimulation with IFN-gamma. We suggest that human myoblasts may constitute a local source of C and therefore C could be implicated in inflammatory or physiopathological processes developed in skeletal muscle.

References

Apr 1, 1978·The Journal of Experimental Medicine·V A LennonR Ulevitch
Nov 21, 1991·The New England Journal of Medicine·M C Dalakas
Apr 1, 1990·Annals of Neurology·A M Emslie-Smith, A G Engel
Feb 6, 1986·The New England Journal of Medicine·J T KisselK W Rammohan
Mar 1, 1985·Muscle & Nerve·E SchultzC R Valliere
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·H M Blau, C Webster
Feb 1, 1994·Human Gene Therapy·J E Morgan
Jun 1, 1994·Immunology Today·R Hohlfeld, A G Engel
Jun 23, 1994·The New England Journal of Medicine·D B Drachman
Jul 1, 1993·Journal of Neuropathology and Experimental Neurology·R R Heffner
May 1, 1993·The Journal of Clinical Investigation·J A HalperinA Nicholson-Weller

❮ Previous
Next ❯

Citations

Jun 3, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Martin J RutkowskiAndrew T Parsa
May 5, 2004·Fish & Shellfish Immunology·Sigrun LangeBergljót Magnadóttir
Aug 6, 2011·The Journal of Surgical Research·Sathnur B PushpakumarClaudio Maldonado
Oct 11, 2015·Bone·Priya Londhe, Denis C Guttridge
Dec 13, 2006·The Journal of Investigative Dermatology·Sung June ByunTae-Yoon Kim
May 15, 2013·Seminars in Immunology·Jonathan D Leslie, Roberto Mayor
Nov 19, 2004·American Journal of Physiology. Cell Physiology·Susan K TsivitseFrancis X Pizza
Aug 11, 2011·American Journal of Physiology. Endocrinology and Metabolism·Frode NorheimFred Haugen
Mar 21, 2008·American Journal of Physiology. Cell Physiology·Ming ChengTimothy J Koh
Dec 11, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shinya WatanabeMotoyuki Iemitsu
Nov 16, 2002·Journal of Applied Physiology·Thomas J McLoughlinFrancis X Pizza
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuko KimuraKatia Del Rio-Tsonis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.