Complement Complex C5b-9 Levels Are Associated with the Clinical Outcomes of Acute Ischemic Stroke and Carotid Plaque Stability

Translational Stroke Research
Weixin SiHong Zhang

Abstract

The terminal complement complex C5b-9 plays an important role in acute ischemic stroke (AIS) and carotid atherosclerosis. However, the associations between serum C5b-9, the severity and outcome of AIS, and the stability of carotid plaques have not been well investigated. In this clinical study, 70 patients with AIS and 70 healthy controls were enrolled. Serum C5b-9 levels at 72 h after stroke onset were measured by enzyme-linked immunosorbent assay (ELISA). Infarct size, the National Institutes of Health Stroke Scale (NIHSS), the 90-day modified Rankin Scale (mRS), and carotid plaque and stenosis were evaluated. Serum C5b-9 levels were significantly higher in AIS patients than in healthy controls (p < 0.001) and were correlated with infarction sizes (p = 0.045) and the NIHSS (P = 0.035). Furthermore, 90-day mRS analysis demonstrated that the patients with poor outcomes had higher serum C5b-9 levels than those with good outcomes (P < 0.001). Moreover, serum C5b-9 levels in AIS patients with unstable carotid plaques were much higher than in those with stable carotid plaques (P = 0.009). Multivariate logistic regression indicated that C5b-9 could be an independent risk factor for AIS (P < 0.001) and unstable carotid plaques (P = 0...Continue Reading

References

Apr 12, 2001·The New England Journal of Medicine·M J Walport
Feb 13, 2003·Journal of Neuropathology and Experimental Neurology·Gary H Danton, W Dalton Dietrich
Jan 20, 2004·Ultrasound Quarterly·Edward G GrantUNKNOWN Society of Radiologists in Ultrasound
Jun 16, 2004·Clinical and Experimental Immunology·E D PedersenT E Mollnes
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fleur BossiFrancesco Tedesco
Jul 11, 2006·Neurosurgery·J MoccoE Sander Connolly
Mar 7, 2009·Stroke; a Journal of Cerebral Circulation·Mathias GelderblomTim Magnus
Feb 5, 2010·Journal of Leukocyte Biology·Rong JinGuohong Li
Dec 16, 2010·Journal of Thrombosis and Haemostasis : JTH·W S SpeidlJ Wojta
Nov 5, 2011·Stroke; a Journal of Cerebral Circulation·Liping LiuYongjun Wang
Nov 27, 2014·Frontiers in Cellular Neuroscience·Franca OrsiniMaria-Grazia De Simoni
Dec 19, 2014·Circulation·Dariush MozaffarianUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Oct 17, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Dandan ZhaoXinyue Chen
Nov 19, 2015·Microbiology and Immunology·Eszter TubolyHidechika Okada

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Citations

Mar 5, 2019·Neuromolecular Medicine·Joseph Kamtchum-Tatuene, Glen C Jickling
Aug 17, 2019·Frontiers in Immunology·Alison R ClarkeE Sander Connolly

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS

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