Complement component C3 allotypes and outcomes in liver transplantation

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Navdeep DhillonBernd Schröppel

Abstract

The complement system has been implicated in the pathogenesis of liver diseases. Human complement component C3 (C3) exists as 2 allotypes, fast (F) and slow (S). We conducted a study to address the influence of these alleles on ischemia-reperfusion (IR) injury and graft survival in liver transplant recipients. Four hundred thirty patients receiving liver transplants from 2000 to 2004 were included. C3 allotypes of 296 donor-recipient pairs were determined and correlated with clinical outcomes. Four groups were analyzed according to the C3 genotype: C3 SS donor and recipient, C3 FS or C3 FF donor and C3 SS recipient, C3 SS donor and C3 FS or C3 FF recipient, and C3 FS or C3 FF donor and recipient. Baseline characteristics of the 4 groups were similar. The mean follow-up time was 4.3 +/- 2.2 years. The 4 groups had similar rates of IR injury (P = 0.16). The hazard ratios for liver allograft survival in the C3 SS donor and recipient group in comparison with the other 3 groups (C3 FS or C3 FF donor and C3 SS recipient, C3 SS donor and C3 FS or C3 FF recipient, and C3 FS or C3 FF donor and recipient) were not significantly different: 1.13 (P = 0.60), 0.99 (P = 0.97), and 1.02 (P = 0.95), respectively. In conclusion, donor and recipi...Continue Reading

References

Oct 1, 1990·The Journal of Experimental Medicine·M BottoM J Walport
Mar 1, 1993·Clinical and Experimental Immunology·J E Finn, P W Mathieson
Sep 9, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·G TestaG B Klintmalm
Apr 25, 2003·Experimental and Molecular Pathology·Constantino FondevilaJerzy W Kupiec-Weglinski
Sep 17, 2003·The Journal of Experimental Medicine·Christoph W StreyJohn D Lambris
Jan 25, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Stefano Ginanni CorradiniMassimo Rossi
May 12, 2006·The New England Journal of Medicine·Katherine M BrownNeil S Sheerin
Apr 26, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Paul J ThuluvathHwan Y Yoo
Jul 20, 2007·The New England Journal of Medicine·John R W YatesUNKNOWN Genetic Factors in AMD Study Group
Jan 2, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bin GaoZhigang Tian
Sep 19, 2008·Journal of Cellular and Molecular Medicine·Maciej M MarkiewskiJohn D Lambris
Dec 17, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·H Thomas LeeVivette D D'Agati
Feb 28, 2009·The New England Journal of Medicine·Mira VaragunamGerhard Opelz

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Citations

Dec 5, 2013·Pathology·Joris R DelangheMarijn M Speeckaert
Nov 2, 2016·Clinical Transplantation·Diana María Valero-HervásEstela Paz-Artal
Aug 16, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marc HilhorstUNKNOWN Limburg Renal Registry
Apr 6, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Grecia M Marrón-LiñaresManuel Hermida-Prieto
Oct 17, 2019·Frontiers in Immunology·Tineke Kardol-HoefnagelHenderikus G Otten
Jun 15, 2021·International Journal of Hepatology·Maria PiresJ Michael Tredger

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