Complement deficiencies in selected groups of patients with meningococcal disease

Scandinavian Journal of Infectious Diseases
H E NielsenI Lind

Abstract

We have examined 125 individuals who have earlier had meningococcal (mgc) disease. They belonged to one or more of the following groups: (1) 2 or more cases of mgc disease in the same family; (2) individuals with 2 episodes of mgc disease or with 1 episode of mgc disease and 1 or more episodes of purulent meningitis of another aetiology; and (3) infections with Neisseria meningitidis belonging to serogroups that are uncommon as causes of disease and presumably low-virulent (W-135, 29E, X, Y). Among these we found 15 complement (C)-deficient individuals (12%). The prevalence of C deficiency in the groups above was 7%, 41% and 19%, respectively. The first group (family cases), is very heterogeneous and may be further subdivided into 2 groups: families whose members fell ill within an interval of 30 days (in these the prevalence of C deficiency was 2%), and families in which the interval between mgc disease cases exceeded 30 days (in those the prevalence of C deficiency was 14%). We found a predominance of defects of the initiation pathways, with properdin deficiency being the most common.

References

Nov 5, 1977·Lancet·T AkogluP Trenchef
Apr 1, 1977·Journal of the American Podiatry Association·E J Harris
Nov 8, 1986·British Medical Journal·L DurhamA Bowden
Jul 7, 1988·The New England Journal of Medicine·A G SjöholmH C Zanen
Jan 1, 1987·Scandinavian Journal of Infectious Diseases·H E Nielsen, C Koch
Aug 1, 1987·Clinical Immunology and Immunopathology·H E Nielsen, C Koch
Dec 1, 1986·Scandinavian Journal of Immunology·J TschoppP Späth
Mar 1, 1987·American Journal of Epidemiology·K KrasinskiH Kusmiesz
Jun 1, 1969·The Journal of Experimental Medicine·I GoldschneiderM S Artenstein
Aug 1, 1983·The Journal of Infectious Diseases·J MerinoB Casanueva
Jul 1, 1982·Acta Psychologica·R G Crowder
Feb 20, 1950·Acta Medica Scandinavica·J PIPER

❮ Previous
Next ❯

Citations

Mar 4, 2000·Molecular Immunology·C A FijenE J Kuijper
Dec 12, 2001·Vaccine·S L Morley, A J Pollard
Jan 13, 2000·Clinical and Experimental Immunology·Z ZhuJ E Volanakis
Sep 1, 1993·Acta Paediatrica·M SchlesingerZ Fishelson
Oct 1, 1990·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A G Sjöholm
Dec 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H E NielsenT Vikingsdottir
Jul 16, 2008·Clinical Microbiology Reviews·Marc Tebruegge, Nigel Curtis
Oct 12, 2010·Clinical Microbiology Reviews·Sanjay RamPeter A Rice
Jul 9, 2010·Clinical Microbiology Reviews·Matthijs C BrouwerDiederik van de Beek
Oct 8, 2004·BMC Family Practice·Christopher BoosMatthew Dawes
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Youssif Mohammed AliWilhelm J Schwaeble
Sep 1, 1995·European Journal of Pediatrics·H H DerkxS J van Deventer
Jan 5, 2011·Médecine et maladies infectieuses·R AbdelmalekT Ben Chaabane
Apr 3, 2007·Trends in Microbiology·Muriel C SchneiderChristoph M Tang
Aug 1, 1992·Clinical Immunology and Immunopathology·A E PlatonovL V Serebrovskaya
Jan 20, 2007·FEMS Microbiology Reviews·Simon Nadel, J Simon Kroll
Oct 10, 2013·Virulence·Lisa A Lewis, Sanjay Ram
Dec 24, 2014·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·C de MarcellusT Guiddir
Jan 1, 1993·International Reviews of Immunology·R B SimV M Dee
Jan 1, 1993·International Reviews of Immunology·F TedescoS Perissutti
Jan 1, 1990·Scandinavian Journal of Infectious Diseases·S RogdeB Olaisen
Apr 1, 1993·Scandinavian Journal of Immunology·K HøgåsenG Bjune
Feb 1, 1993·Journal of the Royal Army Medical Corps·D P WhitehouseS P Sahi
Sep 21, 2001·Immunology and Cell Biology·H T ChanA Jaworowski
Jun 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarika AgarwalSanjay Ram
Feb 19, 2020·Human Genetics·Stephanie HodeibVanessa Sancho-Shimizu
Oct 1, 1994·Clinical Microbiology Reviews·J Diaz Romero, I M Outschoorn
Jul 1, 1991·Clinical Microbiology Reviews·J E Figueroa, P Densen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.