Complement-dependent injury and protection in a murine model of acute dextran sulfate sodium-induced colitis.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Jennifer Schepp-BerglindStephen Tomlinson

Abstract

Complement plays a key role in the pathophysiology of many inflammatory diseases, and in this study, we investigated the role of complement in the pathogenesis of inflammatory bowel disease. Compared to wild-type mice, mice deficient in C3 or factor B were protected from acute dextran sulfate sodium (DSS)-induced colitis. C1q/mannose-binding lectin (MBL) double-deficient mice, however, exhibited more severe colitis than wild-type mice. When mice were allowed to recover after DSS treatment, all C1q/MBL(-/-) mice died by day 2 of recovery period, and, surprisingly, all C3(-/-) and factor B(-/-) mice died by day 5. Serum endotoxin levels were significantly increased in complement-deficient mice prior to death, particularly in C1q/MBL(-/-) mice, and antibiotic treatment prevented the lethal effect of DSS in all complement-deficient mice. In contrast to complement deficiency, targeted complement inhibition with either complement receptor 2 (CR2)-Crry (blocks all pathways at C3 activation) or CR2-factor H (blocks alternative pathway) was highly protective at treating established acute colitis. Endotoxin levels remained low in complement-inhibited mice, and complement inhibition also reduced inflammatory cytokines, leukocyte infiltrat...Continue Reading

References

Jan 1, 1991·Immunologic Research·T S Halstensen, P Brandtzaeg
May 10, 1990·The New England Journal of Medicine·O AhrenstedtR Hällgren
Jan 28, 2003·The American Journal of Pathology·Gregory L StahlHui Zhao
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Trent M WoodruffStephen M Taylor
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Feng LinM Edward Medof
Oct 28, 2006·The Journal of Biological Chemistry·Kay JohswichAndreas Klos
Jul 11, 2008·Immunological Reviews·V Michael Holers
Nov 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuxiang HuangStephen Tomlinson
Oct 16, 2009·The Journal of Pharmacology and Experimental Therapeutics·Xiao-dong PengYu-quan Wei
Feb 26, 2010·Immunogenetics·Christina HoffmannAndreas Weimann
Mar 27, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Fengxin LuAlvin E Davis
Jan 26, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katja DahlkeNiels C Riedemann
Jun 28, 2011·Scandinavian Journal of Gastroenterology·Leokadia Bak-RomaniszynMaciej Cedzynski

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Citations

May 17, 2014·Inflammatory Bowel Diseases·Umang JainAndrew W Stadnyk
May 6, 2015·Inflammatory Bowel Diseases·Umang JainAndrew W Stadnyk
Oct 31, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·Katherine E Degen, Robert G Gourdie
Dec 4, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hwei-Fang TsaiPing-Ning Hsu
Oct 27, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Irene D RománLuis G Guijarro
Jul 9, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshihiro FukuokaLawrence B Schwartz
Oct 25, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lin ZouWei Chao
Mar 8, 2013·International Journal of Molecular Medicine·Toshifumi TsujiToshikazu Yoshikawa
Oct 9, 2020·Medical Molecular Morphology·Naohiko GunjiHiromasa Ohira
Mar 12, 2021·Frontiers in Cellular and Infection Microbiology·Patricia M SikorskiMichael E Grigg

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