PMID: 8982108Dec 1, 1996Paper

Complement expression on astrocytes and astrocytoma cell lines: failure of complement regulation at the C3 level correlates with very low CD55 expression

Journal of Neuroimmunology
O B SpillerD V Devine

Abstract

Primary fetal human astrocytes and an astrocytoma cell line, U373-MG, expressed membrane cofactor protein (CD46), CD59, and low levels of decay-accelerating factor (CD55). Astrocyte CD55 was capable of regulating C3 deposition on the cell surface; albeit at a lower level than primary human fibroblasts. Negligible complement-mediated lysis of primary astrocytes and the U373-MG cell line was observed, even when large amount of astrocyte-specific, complement-activating antibodies were bound to the cells. Blocking the function of CD59 on astrocytes resulted in a > 90% cell lysis, while equivalent lysis of fibroblasts could only be achieved with additional blocking of CD55.

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Citations

Aug 26, 2004·Journal of Neuroinflammation·Masato HosokawaPatrick L McGeer
Aug 25, 2009·Neuroscience·S R HinsonV A Lennon
Apr 25, 2009·Autoimmunity Reviews·Philippe SaikaliThierry Vincent
Sep 18, 2009·Annals of the New York Academy of Sciences·Romain CayrolThierry Vincent
Jul 20, 2010·Nature Reviews. Neurology·Sven Jarius, Brigitte Wildemann
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thierry VincentJack P Antel
Jul 19, 2000·Biochimica Et Biophysica Acta·M R EmmerlingK Spiegel

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