Complement Factor H as a potential atherogenic marker in chronic Chagas' disease.

Parasite Immunology
K C F LidaniI J Messias-Reason

Abstract

We aimed to investigate the association between plasma levels of complement Factor H (FH) with cardiac involvement, inflammatory and cardiometabolic parameters in patients with chronic Chagas' disease (CD). FH plasmatic levels were determined in 80 chronic CD patients. Glycaemic index, lipidogram (high-density lipoprotein cholesterol HDL-C, low-density lipoprotein cholesterol LDL-C, triglycerides and total cholesterol) and Ultrasensitive C-Reactive Protein (uCRP) values were obtained from medical records. Height, weight, body mass index (BMI) blood pressure and left ventricular ejection fraction (LVEF) were obtained from echocardiography examinations. Comparisons between chronic CD clinical forms were performed using Mann-Whitney test and correlation Spearman's test. FH levels were correlated positively with triglycerides (P = .001, r = .39), LDL-C (P = .009, r = .3), cholesterol (P = .02, r = .28), uCRP (P = .029, r = .31) and BMI (P = .008, r = .34); and negatively with HDL-C (P = .03, r = -.25) levels. Dyslipidemic patients showed higher FH levels compared to normolipidemic, although no difference for FH levels was observed between chronic CD clinical forms. Alternative pathway of complement may be a link between immune resp...Continue Reading

References

Jul 1, 1989·Revista Da Sociedade Brasileira De Medicina Tropical·J C Dias
Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·H B TanowitzM Wittner
Jul 20, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·G M NakedL Isaac
Feb 15, 2001·Arquivos brasileiros de cardiologia·A RassiA Rassi
May 28, 2004·Molecular Immunology·Santiago Rodríguez de CórdobaPilar Sánchez-Corral
Mar 7, 2007·Circulation·Jose Antonio Marin-NetoMarcus V Simões
Aug 30, 2007·BMC International Health and Human Rights·Carlos Franco-ParedesJorge Mendez
Jul 8, 2008·Trends in Immunology·Mihály Józsi, Peter F Zipfel
Sep 29, 2009·Molecular Immunology·Igor dos S CestariMarcel I Ramirez
Oct 17, 2009·Diabetes·José María Moreno-NavarreteJosé Manuel Fernández-Real
Oct 24, 2009·The Journal of Biological Chemistry·Azubuike I OkemefunaStephen J Perkins
Oct 27, 2009·International Journal of Cardiology·Paola R LuzIara J Messias-Reason
Jun 29, 2010·Molecular Immunology·Viviana P FerreiraClaudio Cortés
Aug 20, 2010·Nature Immunology·Daniel RicklinJohn D Lambris
Apr 15, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Angelica B W BoldtIara J T Messias-Reason
Sep 10, 2011·Current Neurology and Neuroscience Reports·Marco Oliveira Py
Feb 9, 2012·Cellular Microbiology·Fnu NagajyothiHerbert B Tanowitz
Feb 22, 2012·Journal of Cellular and Molecular Medicine·Ileana Manduteanu, Maya Simionescu
Apr 6, 2012·Current Infectious Disease Reports·José A Pérez-MolinaRogelio López-Vélez
Mar 8, 2013·International Journal of Cardiology·Abrão AbuhabFernando Bacal
Apr 18, 2013·PloS One·Paola R LuzIara J T Messias-Reason
May 16, 2013·Scandinavian Journal of Immunology·S E Degn, S Thiel
Jul 24, 2013·The Journal of Infectious Diseases·John R KoetheKevin Niswender
Oct 22, 2013·Acta Tropica·Francisco Rogerlândio Martins-MeloJorg Heukelbach
Dec 25, 2013·Arquivos brasileiros de cardiologia·H T XavierJ A F Ramires
Feb 4, 2014·Microbes and Infection·Christopher JohndrowFnu Nagajyothi
Jun 7, 2014·Circulation Research·Jacob Fog BentzonErling Falk
Oct 3, 2014·PLoS Neglected Tropical Diseases·Fnu NagajyothiHerbert B Tanowitz
Oct 3, 2014·Mediators of Inflammation·Qianqian Miao, Momar Ndao
Dec 19, 2014·Circulation·Dariush MozaffarianUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Apr 29, 2015·International Journal of Cardiology·Kárita Cláudia Freitas LidaniIara José de Messias-Reaso
Sep 27, 2015·Global Heart·Jeffrey D Stanaway, Gregory Roth
Oct 7, 2015·Molecular Neurodegeneration·Manasi MalikSteven Estus
Jan 9, 2016·PLoS Neglected Tropical Diseases·Paola Rosa LuzIara J Messias-Reason
Jan 13, 2016·Immunologic Research·Sonia I VlaicuHorea Rus
Feb 3, 2016·Frontiers in Immunology·Mariana S CardosoDaniella C Bartholomeu
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katrine PilelyPeter Garred

❮ Previous
Next ❯

Citations

Aug 18, 2018·Frontiers in Immunology·Anna E van BeekKyra A Gelderman
Mar 10, 2021·Parasite Immunology·Kárita Cláudia Freitas LidaniIara J Messias-Reason

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.