PMID: 627834Jan 1, 1978Paper

Complement-mediated killing of schistosomula of Schistosoma mansoni by rat eosinophils in vitro

The Journal of Experimental Medicine
F J Ramalho-PintoS R Smithers

Abstract

Eosinophils from the peritoneal cavity of normal rats, in the presence of fresh normal rat serum (NRS), adhered to schistosomula of Schistosoma mansoni in vitro and killed the majority of parasites within 18 h. The reaction differed from the previously described antibody-mediated eosinophil adherence to schistosomula which occurs in heat-inactivated immune rat serum (IRS) and where adherence is mediated through Fc receptors. Adherence of eosinophils in fresh NRS was shown to be due to the activation of complement at the schistosomular surface by the alternative pathway, and it was effected through C3 receptors. The ability of eosinophils to kill in Fc-mediated adherence. This enhancement of killer activity may be due to the generation by complement activation of eosinophil chemotactic factors which increase the concentration of cells at the target surface. It is suggested that eosinophil adherence mediated through complement activation could be the principla mechanism of destroying schistosomula in the host.

References

Dec 1, 1974·Experimental Parasitology·F J Ramalho-PintoJ Pellegrino
Nov 1, 1968·The Journal of Experimental Medicine·W H Lay, V Nussenzweig
Oct 6, 1969·Annals of the New York Academy of Sciences·S R Smithers, R J Terry
Jun 1, 1970·The Journal of Experimental Medicine·A BastenP B Beeson

Citations

Dec 1, 1980·Acta Tropica. Supplementum·L Haller
Nov 3, 2010·Cell and Tissue Research·Revital ShamriLisa A Spencer
Oct 1, 1986·International Journal for Parasitology·P E Simonsen, B J Andersen
Nov 1, 1990·International Journal for Parasitology·J AndreassenD Befus
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·C F Nathan
Mar 1, 1984·Molecular and Biochemical Parasitology·M Philipp, F D Rumjaneck
Nov 1, 1984·Molecular and Biochemical Parasitology·F Levi-SchafferM Smolarsky
Jan 1, 1989·Parasitology Today·Z Fishelson
Apr 1, 1978·The Australian Journal of Experimental Biology and Medical Science·S J ProwseC R Jenkin
Dec 10, 1999·The Biochemical Journal·R Tarrab-HazdaiR Arnon
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D S Silberstein, J R David
May 1, 1985·The Journal of Cell Biology·J C Samuelson, J P Caulfield
Aug 1, 1982·The Journal of Cell Biology·J C SamuelsonJ R David
May 1, 1994·The Journal of Experimental Medicine·M ParizadeZ Fishelson
May 17, 2006·The Journal of Experimental Medicine·David VoehringerRichard M Locksley
Jun 1, 1979·Journal of Immunogenetics·F H Claas, A M Deelder
Jun 17, 2000·Infection and Immunity·M FeldmesserA Casadevall
Aug 1, 1982·The Journal of Clinical Investigation·J J EllnerK L Edmonds
Jan 1, 1984·The Journal of Clinical Investigation·S P Sass-KuhnA B Kay
Apr 1, 1985·The Journal of Clinical Investigation·J W KazuraM Aikawa
Jan 27, 2004·The Journal of Parasitology·Ariela Freudenstein-DanZ Fishelson
Jan 1, 1981·Critical Reviews in Clinical Laboratory Sciences·M Tavassoli
Oct 1, 2007·Expert Opinion on Drug Discovery·Bernadette RamirezSolomon Nwaka
Jun 14, 2008·Acta Tropica·Denise Silveira-LemosRodrigo Corrêa-Oliveira
Aug 1, 1979·Experimental Parasitology·H C GreenblattS I Morse
Jun 1, 1984·Experimental Parasitology·D Hoole, J B Mitchell
Aug 1, 1982·Experimental Parasitology·F SantoroA Capron
Apr 1, 1982·Experimental Parasitology·D J McLaren, R N Incani
Apr 1, 1981·Experimental Parasitology·T B McGuinness, W M Kemp
Oct 1, 1980·Experimental Parasitology·W Dias Da Silva, M D Kasatchkine
Mar 1, 1987·Parasite Immunology·K R Rasmussen, W M Kemp
Mar 1, 1983·Parasite Immunology·C H KingB M Greene
Nov 1, 1986·Parasite Immunology·C M PrestonD J McLaren
Mar 1, 1982·Parasite Immunology·D J McLaren, R J Terry
Jan 1, 1981·Parasite Immunology·C Davies, J Goose
Jan 1, 1982·Immunological Reviews·A CapronG Torpier
Jan 1, 1982·Immunological Reviews·A E ButterworthE Wells
Mar 1, 1991·Kisaengch'unghak chapchi. The Korean journal of parasitology·P R ChungC T Soh
May 10, 2001·The Journal of Allergy and Clinical Immunology·F D Finkelman, J F Urban
Sep 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P C de GroenJ Ludwig
May 1, 1992·Revista Do Instituto De Medicina Tropical De São Paulo·A L MeloC R Machado
Jan 1, 1993·Revista Do Instituto De Medicina Tropical De São Paulo·A L de MeloL H Pereira
Jan 18, 1979·Nature·G HuldtH U Schorlemmer
Jul 10, 2019·Infection and Immunity·Anupama Ariyaratne, Constance A M Finney
Dec 31, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia Esser-von BierenNicola L Harris
Jan 1, 1986·Revista Da Sociedade Brasileira De Medicina Tropical·P RasoJ Neves
Jan 1, 1980·Scandinavian Journal of Infectious Diseases. Supplementum
Jan 19, 2018·International Immunology·Koubun Yasuda, Kenji Nakanishi
Dec 4, 2019·Immunological Medicine·Koubun Yasuda, Etsushi Kuroda
Oct 13, 2020·Frontiers in Immunology·Sofía FrigerioTeresa Freire
Jan 8, 2000·The Journal of Biological Chemistry·M OwhashiN Hayai

Related Concepts

Cell Adhesion
Chemotaxis, Leukocyte
Complement C3 precursor
Eosinophil
Immunoglobulin Fc Fragments
Schistosoma mansoni
Katayama Fever

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