Nov 1, 1977

Complement-mediated release of histamine from human basophils. III. Possible regulatory role of microtubules and microfilaments

The Journal of Allergy and Clinical Immunology
J A GrantD O Thueson

Abstract

The release of histamine by normal human leukocytes (basophils) following in vitro challenge with activated complement (zymosan-treated serum) was previously reported. In this study, the effects of various pharmacologic agents on this release mechanism were compared with allergen-induced release of histamine. Colchicine and vinblastine antagonize the polymerization of tubulin to form microtubules, and both agents inhibited complement-and allergen-triggered release of histamine from basophils. Finally, treatment with cytochalasin B, a fungal product known to interfere with microfilament formatin, resulted in enhanced release of histamine from complement-treated basophils but no significant change in the percentage of histamine released from allergen-treated basophils. These findings suggest that microtubules and/or microfilaments are involved in complement-induced secretion of histamine by human basophils.

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Mentioned in this Paper

Histamine Measurement
Vinblastine
Basophils
SpecimenType - Basophils
White Blood Cell Count Procedure
Allergens
Process of Secretion
Allergen (brand of diphenylpyraline)
Microtubules
Leukocytes

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