Complement modulating activity of Rwandan medicinal plants

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
P CosA Vlietinck

Abstract

Forty-two ethanolic extracts of thirty-six Rwandan medicinal plants were investigated for their influence on complement-mediated hemolysis. The plants were selected on the base of their ethnomedicinal use in infections and autoimmune diseases. Eight plant extracts showed an inhibitory activity against the classical pathway of the complement system and ten plant extracts against the alternative pathway. Three plant extracts exhibited an interesting activity against both pathways, i.e. Aspilia pluriseta, Coleus kilimandschari, and Macaranga kilimandscharica (leaves and stem). Further study indicated that the complement inhibitory activity was not caused by chelation of bivalent cations or by direct action on the target erythrocytes.

References

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Citations

Feb 22, 2012·Chemistry & Biodiversity·Daniela A Chagas-PaulaFernando B Da Costa
May 18, 2011·Journal of Ethnopharmacology·Torunn StangelandKåre A Lye
Oct 8, 2013·Journal of Ethnopharmacology·Léocadie KamagajuPierre Duez
Feb 11, 2021·BMC Research Notes·Sospeter N Njeru, Jackson M Muema
Dec 29, 2020·Fitoterapia·Daniel UmerewenezaAdolf Gogoll
Feb 1, 2020·Journal of Ethnopharmacology·Elise GeromettaAnne Gauvin-Bialecki
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jean Claude Didelot TomaniJacob Souopgui

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