PMID: 6767453Mar 1, 1980

Complement, opsonins, and the immune response to bacterial infection in burned patients

Annals of Surgery
A B BjornsonH S Bjornson


Studies were performed to evaluate complement, opsonins, and the immune response to bacterial infection in burned patients. Concentrations and functional acitivities of components of the classical and alternative complement pathways were measured in the sera of four septic, two bacteremic, and four nonseptic burned patients. In addition, heat-labile and heat-stable opsonic activity and agglutinin titers directed against the infecting bacterial strains were measured in the sera of the four septic patients and in an additional group of 11 septic burned patients with abnormal complement profiles. Functional activity of the alternative complement pathway and the concentration of properdin were shown to be persistently decreased during eight weeks postburn in the septic, bacteremic, and nonseptic burned patients; reduced classical pathway activity was demonstrated during the initial postburn period only in the septic patients. Two of the 15 septic patients had decreased heat-labile serum opsonic activity for their infecting bacterial strains, which occurred only during the initial postburn period. Heat-stable opsonins and agglutinin titers in the patients' sera directed against the infecting bacterial strains were equivalent to thos...Continue Reading


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Related Concepts

Antibodies, Bacterial
Bacterial Infections
Blood Transfusion
Burn Injury
Hemolytic Complement
Complement Pathway, Alternative
Complement Pathway, Classical
Alkalescens-Dispar Group

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