PMID: 6767453Mar 1, 1980

Complement, opsonins, and the immune response to bacterial infection in burned patients

Annals of Surgery
A B BjornsonH S Bjornson

Abstract

Studies were performed to evaluate complement, opsonins, and the immune response to bacterial infection in burned patients. Concentrations and functional acitivities of components of the classical and alternative complement pathways were measured in the sera of four septic, two bacteremic, and four nonseptic burned patients. In addition, heat-labile and heat-stable opsonic activity and agglutinin titers directed against the infecting bacterial strains were measured in the sera of the four septic patients and in an additional group of 11 septic burned patients with abnormal complement profiles. Functional activity of the alternative complement pathway and the concentration of properdin were shown to be persistently decreased during eight weeks postburn in the septic, bacteremic, and nonseptic burned patients; reduced classical pathway activity was demonstrated during the initial postburn period only in the septic patients. Two of the 15 septic patients had decreased heat-labile serum opsonic activity for their infecting bacterial strains, which occurred only during the initial postburn period. Heat-stable opsonins and agglutinin titers in the patients' sera directed against the infecting bacterial strains were equivalent to thos...Continue Reading

References

Apr 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D T Fearon, K F Austen
Jun 1, 1977·The Journal of Surgical Research·C L Miller, D D Trunkey
Jul 1, 1977·Annals of Surgery·A B BjornsonH S Bjornson
Jul 1, 1976·Annals of Surgery·F T Rapaport, R J Bachvaroff
Nov 1, 1974·The Journal of Experimental Medicine·R D Schreiber, H J Müller-Eberhard
Jan 1, 1974·The Journal of Experimental Medicine·O Götze, H J Müller-Eberhard
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Aug 1, 1969·Archives of Surgery·J W AlexanderW A Altemeier
Jun 1, 1972·Postgraduate Medical Journal·J Kohn
Jul 1, 1966·Archives of Surgery·J W Alexander, J A Moncrief
Aug 1, 1965·The Journal of Experimental Medicine·U R NILSSON, H J MUELLER-EBERHARD

Citations

Jun 1, 1996·Burns : Journal of the International Society for Burn Injuries·G Arturson
Jun 7, 2003·The Journal of Burn Care & Rehabilitation·H J KangK M Lee
Jan 1, 1984·Scandinavian Journal of Plastic and Reconstructive Surgery·B Alsbjörn
Sep 1, 1992·The Journal of Surgical Research·R G Miller, A N Neely
May 5, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M J WiezerP A van Leeuwen
Jul 1, 1984·Clinical Pediatrics·F S VirantA H Novack
Feb 1, 1986·Acta Anaesthesiologica Scandinavica·J PerttiläM Salo
Aug 18, 2017·Journal of Neurotrauma·Francesco RoselliMarkus Huber-Lang
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manabu KinoshitaShuhji Seki

Related Concepts

Agglutinins
Antibodies, Bacterial
Bacterial Infections
Blood Transfusion
Burn Injury
Hemolytic Complement
Complement Pathway, Alternative
Complement Pathway, Classical
Alkalescens-Dispar Group
Opsonin

Related Feeds

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.