Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection.

Frontiers in Immunology
György SinkovitsZ Prohászka


Uncontrolled thromboinflammation plays an important role in the pathogenesis of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus. Complement was implicated as key contributor to this process, therefore we hypothesized that markers of the complement profile, indicative for the activation state of the system, may be related to the severity and mortality of COVID-19. In this prospective cohort study samples of 102 hospitalized and 26 outpatients with PCR-confirmed COVID-19 were analyzed. Primary outcome was in-hospital, COVID-19 related mortality, and secondary outcome was COVID-19 severity as assessed by the WHO ordinal scale. Complement activity of alternative and classical pathways, its factors, regulators, and activation products were measured by hemolytic titration, turbidimetry, or enzyme-immunoassays. Clinical covariates and markers of inflammation were extracted from hospital records. Increased complement activation was characteristic for hospitalized COVID-19 patients. Complement activation was significantly associated with markers of inflammation, such as interleukin-6, C-reactive protein, and ferritin. Twenty-five patients died during hospital stay due to COVID-19 related illness. Patients with uncontrolled com...Continue Reading


May 1, 1991·The American Review of Respiratory Disease·A B BjornsonG M Schiff
Nov 10, 1988·Journal of Immunological Methods·C DelamarcheJ Emile
Apr 5, 2001·The New England Journal of Medicine·M J Walport
Apr 16, 2003·The New England Journal of Medicine·Nelson LeeJoseph J Y Sung
Apr 25, 2003·Lancet·J S M PeirisUNKNOWN SARS study group
Oct 15, 2003·Trends in Microbiology·Sun-Hwa LeeRobert E Means
May 11, 2011·Proceedings of the National Academy of Sciences of the United States of America·Meike HeurichClaire L Harris
Mar 1, 2012·Journal of Thrombosis and Haemostasis : JTH·M RétiZ Prohászka
Oct 19, 2012·The New England Journal of Medicine·Ali M ZakiRon A M Fouchier
Jun 16, 2015·Frontiers in Immunology·Nicolas S MerleLubka T Roumenina
Jun 18, 2015·Frontiers in Immunology·Nicolas S MerleLubka T Roumenina
Aug 1, 2016·Immunobiology·Zoltán ProhászkaMichael Kirschfink
Jun 24, 2018·Molecular Immunology·Zoltán ProhászkaAshley Frazer-Abel
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Apr 18, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Cynthia MagroJeffrey Laurence
Apr 25, 2020·Nature Reviews. Immunology·Antonio M RisitanoJohn D Lambris
Apr 25, 2020·European Review for Medical and Pharmacological Sciences·F DiurnoG Facchini
May 4, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sara MastaglioFabio Ciceri
May 29, 2020·European Journal of Preventive Cardiology·Joris R DelangheMarijn M Speeckaert
Aug 5, 2020·Nature Medicine·Vijendra RamlallSagi D Shapira
Aug 11, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jeffrey LaurenceCynthia M Magro
Sep 19, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jan C HolterTom E Mollnes
Sep 28, 2020·Journal of Nephrology·Ruchi MahajanNatalie Somera Uy
Oct 11, 2020·The Journal of Infectious Diseases·Aline H de NooijerUNKNOWN RCI-COVID-19 study group
Oct 21, 2020·Nature Reviews. Nephrology·Luca PericoGiuseppe Remuzzi
Nov 12, 2020·EClinicalMedicine·Djillali AnnaneUNKNOWN Garches COVID 19 Collaborative Group

❮ Previous
Next ❯


Apr 9, 2021·Science Immunology·Bingyu YanMajid Kazemian

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.