PMID: 6908647Jan 1, 1980

Complement proteins and macrophages. II. The secretion of factor B by lipopolysaccharide-stimulated macrophages

Microbiology and Immunology
A MiyamaT Inoue

Abstract

The secretion of factor B by mouse peritoneal macrophages was found to be enhanced following in vivo or in vitro stimulation with lipopolysaccharide (LPS). The intravenous administration of LPS to mice of various strains caused an increased release of factor B but not the release of acid phosphatase by the peritoneal macrophages obtained from the stimulated mice. In vitro stimulation of cultured macrophages with LPS resulted in an enhanced secretion of both factor B and acid phosphatase. The dose-dependent augmentation of factor B secretion by LPS was found in the macrophages from LPS-responsive C3H/HeN mice, whereas the macrophages from LPS-unresponsive C3H/HeJ mice did not respond to either phenol-extracted LPS or butanol-extracted LPS. The ability of LPS to cause the enhancement of factor B secretion by macrophages was abolished by alkali or acid treatment of LPS, indicating that its lipid A part was responsible for the observed effect.

References

Jul 1, 1978·Infection and Immunity·R M AlbrechtS D Horowitz
Sep 1, 1976·The Journal of Experimental Medicine·D C MorrisonD M Jacobs
Jan 1, 1977·International Archives of Allergy and Applied Immunology·S Natsuume-SakaiM Takahashi
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Jul 1, 1947·American Journal of Clinical Pathology·M A ANDERSCH, A J SZCZYPINSKI

Citations

Jan 1, 1983·Springer Seminars in Immunopathology·H P Hartung, U Hadding
Jan 1, 1993·Immunologic Research·A R McPhaden, K Whaley
Dec 22, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M Michael GlovskyKent J Johnson

Related Concepts

Acetic Acids
Acid Phosphatase
Hemolytic Complement
Dose-Response Relationship, Immunologic
Enzyme Precursors
Lipopolysaccharides
Macrophage
Mice, Inbred C3H
Complement Factor Bb
Sodium Hydroxide

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