Complement receptor type 1 (CR1/CD35) expressed on activated human CD4+ T cells contributes to generation of regulatory T cells

Immunology Letters
Katalin TörökAnna Erdei

Abstract

The role of complement in the regulation of T cell immunity has been highlighted recently by several groups. We were prompted to reinvestigate the role of complement receptor type 1 (CR1, CD3) in human T cells based on our earlier data showing that activated human T cells produce C3 (Torok et al. (2012) [48]) and also by results demonstrating that engagement of Membrane Cofactor Protein (MCP, CD46) induces a switch of anti-CD3-activated helper T cells into regulatory T cells (Kemper et al. (2003) [17]). We demonstrate here that co-ligation of CD46 and CD3, the two C3b-binding structures present on activated CD4+ human T cells significantly enhances CD25 expression, elevates granzyme B production and synergistically augments cell proliferation. The role of CR1 in the development of the Treg phenotype was further confirmed by demonstrating that its engagement enhances IL-10 production and reduces IFNγ release by the activated CD4+ T cells in the presence of excess IL-2. The functional in vivo relevance of our findings was highlighted by the immunohistochemical staining of tonsils, revealing the presence of CD4/CD3 double positive lymphocytes mainly in the inter-follicular regions where direct contact between CD4+ T cells and B ly...Continue Reading

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Citations

Oct 27, 2016·Immunological Reviews·Anna ErdeiZsuzsa Bajtay
Mar 2, 2017·Clinical and Experimental Immunology·R LubbersL A Trouw
Apr 21, 2018·Annual Review of Immunology·Erin E WestClaudia Kemper
May 3, 2019·Nature Reviews. Immunology·Edimara S ReisJohn D Lambris
Jun 11, 2017·Journal of Neuroinflammation·K M DanikowskiB S Prabhakar

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