Complement receptors in HIV infection

Immunological Reviews
Cornelia SpethM P Dierich

Abstract

The complement system plays an important role in the antimicrobial defense of the organism. Its components recognize a large variety of pathogens and target them for destruction, either directly by formation of a membrane attack complex or indirectly by recruiting phagocytic cells. In addition, it has several functions in cell activation, clearance of immune complexes, control of inflammatory reactions, chemotaxis and autoimmunity. For mediation of all these tasks of the complement system, complement receptor molecules on the cell surface play a key role. Current knowledge on structure, function, signal transduction and associated molecules is briefly summarized here. The role of complement receptors for human immunodeficiency virus (HIV)-associated pathogenesis is ambiguous and varies depending on cell type. On the one hand, complement receptors support the infected host to manage HIV infection and to defend itself, at least partially, against viral spreading throughout the organism. Such complement receptor-mediated supporting mechanisms are activation of immune cells and lysis of viral particles and infected host cells. On the other hand, HIV employs complement receptors to intrude more easily into various cell types, to bec...Continue Reading

References

Apr 1, 1979·European Journal of Immunology·T SpringerC Milstein
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D T Fearon
May 4, 1992·Annals of the New York Academy of Sciences·J H KehrlA S Fauci
Oct 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G C Douglas, B F King
Jul 1, 1992·Journal of Neuroscience Research·M G EnnasF Gremo
Dec 1, 1992·Free Radical Biology & Medicine·F Müller
Apr 1, 1992·Clinical Immunology and Immunopathology·S BordinR C Page
Mar 1, 1991·Journal of Clinical Immunology·A CarrR Penny
Jan 1, 1991·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·P EikelenboomH Fraser
Nov 1, 1990·Journal of Neuroimmunology·H Akiyama, P L McGeer
May 1, 1987·The Journal of Experimental Medicine·K MitomoK Iida
Oct 1, 1987·The Journal of Experimental Medicine·V H Perry, S Gordon
Jun 1, 1989·The Journal of Experimental Medicine·F SchrieverL M Nadler
Dec 1, 1989·The Journal of Experimental Medicine·C A LowellJ M Ahearn
Jun 15, 1989·Immunology Letters·J D FingerothD M Ambrosino
Jan 1, 1989·Dermatologica·Y FukuokaT E Hugli
Jan 1, 1989·Advances in Immunology·J M Ahearn, D T Fearon
Jan 1, 1989·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A PorwitP Biberfeld
Jan 1, 1985·Archives of Dermatological Research·T BieberM D Kazatchkine

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Citations

Aug 26, 1998·Clinical Immunology and Immunopathology·M Tolnay, G C Tsokos
Apr 5, 2001·The New England Journal of Medicine·M J Walport
Mar 9, 2002·Journal of Virology·Cornelia SpethManfred P Dierich
Jul 2, 2002·American Journal of Respiratory Cell and Molecular Biology·Michele ZorzettoMaurizio Luisetti
Jan 15, 2008·Vaccine·Heribert StoiberManfred P Dierich
Oct 19, 2004·Molecular Immunology·Cornelia SpethSieghart Sopper
May 18, 2004·Journal of Neuroimmunology·Cornelia SpethHans Maier
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H BouhlalN Haeffner Cavaillon

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