Complement regulator C4BP binds to Staphylococcus aureus and decreases opsonization

Molecular Immunology
Pamela S HairKenji M Cunnion

Abstract

Staphylococcus aureus is the major cause of human skin and soft-tissue infections as well as invasive infections like post-operative wound infections, septic arthritis, and osteomyelitis. The complement system plays an important role in the immunological control of many bacteria, but can be inhibited by a variety of strategies including recruitment of complement regulatory proteins like C4b-binding protein (C4BP). These experiments demonstrate that S. aureus opsonization with C4b occurs rapidly in serum and is predominantly initiated by anti-staphylococcal antibodies. Much of the S. aureus-bound C4b is quickly cleaved to the inactive forms iC4b and C4d. Clinical S. aureus strains rapidly bind significant amounts of the complement regulator C4BP from serum. S. aureus also binds purified C4BP. S. aureus-bound C4BP functions as a cofactor for factor I-mediated C4b cleavage to iC4b and C4d. In the absence of factor I, C4BP decreases classical pathway-mediated deposition of C3b on the S. aureus surface by inhibiting the classical pathway C3-convertase. In summary, C4BP is recruited to the S. aureus surface where it functions to inhibit C4 complement effectors, suggesting a previously undescribed immune evasion strategy for this path...Continue Reading

References

Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·I GigliV Nussenzweig
Oct 1, 1978·The Journal of Experimental Medicine·T FujitaV Nussenzweig
Oct 26, 2005·Trends in Microbiology·Suzan H M RooijakkersJos A G van Strijp
Oct 26, 2005·The Journal of Laboratory and Clinical Medicine·Kenji M CunnionPamela S Hair
Aug 3, 2006·Cellular Microbiology·Suzan H M RooijakkersWillem J B van Wamel
Sep 26, 2007·The Journal of Experimental Medicine·Ilse JongeriusSuzan H M Rooijakkers
Jun 12, 2008·The Journal of Infectious Diseases·Pamela S HairKenji M Cunnion
Dec 31, 2008·Infection and Immunity·Angela S BarbosaLourdes Isaac
Jun 30, 2009·International Journal of Antimicrobial Agents·Matthew S Dryden
Dec 22, 2009·Molecular Immunology·Johanna PietikäinenSeppo Meri
Jun 23, 2010·Seminars in Plastic Surgery·Jason H CalhounMark Shirtliff
Aug 3, 2010·The American Journal of Emergency Medicine·Timothy P YoungLance Brown
Sep 10, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·I M GouldA Walker
Oct 12, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Stan Deresinski, Victor Herrera
Nov 17, 2010·Antimicrobial Agents and Chemotherapy·Sebastiaan J van Hal, David L Paterson
Aug 5, 2011·Surgical Infections·Donald E Fry, Philip S Barie

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Citations

Jan 28, 2014·International Journal of Medical Microbiology : IJMM·Peter F Zipfel, Christine Skerka
Aug 11, 2015·Molecular Immunology·Parvathi S KumarKenji M Cunnion
Jan 23, 2015·Journal of Diabetes Research·Clifford T MaurielloKenji M Cunnion
Nov 1, 2016·Infection and Immunity·Fatemeh AskarianMona Johannessen
Oct 1, 2014·The Journal of Biological Chemistry·Anna HenninghamJason N Cole
Nov 9, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jordan L WoehlBrian V Geisbrecht
Jan 10, 2017·Frontiers in Microbiology·Elise S HovinghIlse Jongerius
Aug 3, 2021·Frontiers in Immunology·Hongbin Wang, Mengyao Liu

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