Complement split product C3c in saliva as biomarker for periodontitis and response to periodontal treatment.

Journal of Periodontal Research
Maria Anastasia GrandeYaseelan Palarasah

Abstract

The complement system is engaged in inflammatory reactions both in the periodontal pockets and in the periodontium itself, where it can mediate tissue destruction. The aim of this study was, first, to compare salivary levels of the total complement system protein C3 and its split product, fluid-phase C3c in patients with periodontitis and periodontally healthy controls. Next, to determine if C3 and C3c levels had biomarker potential in diagnosing and monitoring periodontitis and its treatment. We hypothesized that salivary levels of total C3 and the split product C3c associated with the severity of periodontitis and reflected decreased inflammatory activity after periodontal treatment. At baseline, stimulated saliva samples were collected from patients with periodontitis (n = 18) and periodontally healthy controls (n = 15). Subsequently, non-surgical periodontal treatment was performed in the patients, and saliva sampling from patients was repeated two-, six-, and twelve weeks post-treatment (NCT02913248 at clinicaltrials.gov). The patients were grouped as good and poor responders to treatment according to the achieved reduction in bleeding on probing (BOP). Salivary levels of C3 and C3c were quantified using sandwich ELISA. Pa...Continue Reading

Associated Clinical Trials

References

Feb 1, 1975·Journal of Periodontal Research·R AttströmA Sjöholm
May 1, 1978·Journal of Dental Research·P D TotoA Gargiulo
Jan 1, 1991·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·R J Boackle
Jun 1, 1987·Acta Odontologica Scandinavica·A A Nikolopoulou-PapaconstantinouT Kristoffersen
May 1, 1982·Journal of Periodontal Research·E T LallyP C Baehni
Nov 1, 1984·Journal of Periodontal Research·C E NiekrashN P Lang
Jul 9, 2008·BMC Medical Genomics·Thomas BeiklerThomas F Flemmig
Nov 13, 2008·Paediatric and Perinatal Epidemiology·Brian W Whitcomb, Enrique F Schisterman
Sep 4, 2012·Nature Reviews. Microbiology·George HajishengallisMichael A Curtis
May 3, 2013·Journal of Periodontology·Iain L C ChappleUNKNOWN working group 2 of the joint EFP/AAP workshop
May 3, 2013·Journal of Periodontology·Maurizio S TonettiUNKNOWN working group 1 of the joint EFP/AAP workshop
Nov 1, 2013·Kidney International·Matthew C PickeringH Terence Cook
May 9, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomoki MaekawaGeorge Hajishengallis
May 23, 2014·Annals of the Rheumatic Diseases·Jonatan LefflerAnna M Blom
Jul 22, 2014·Journal of Periodontal Research·C DamgaardC H Nielsen
Aug 27, 2015·Advances in Experimental Medicine and Biology·George HajishengallisJohn D Lambris
Feb 9, 2017·Journal of Immunological Methods·Karina Juhl RasmussenYaseelan Palarasah
Jul 28, 2017·Journal of Oral Microbiology·Palle HolmstrupPeter Riis Hansen
Aug 2, 2017·Periodontology 2000·Jørgen Slots
Mar 10, 2018·Journal of Periodontology·Daniel BelstrømPalle Holmstrup
Mar 15, 2018·BMC Oral Health·Sineepat TalungchitSiribang-On Piboonniyom Khovidhunkit
Jun 30, 2018·The Journal of the American Dental Association·Paul I EkeRobert J Genco

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Citations

Mar 4, 2021·Journal of Dental Research·M G BaltaT E Van Dyke
Apr 23, 2021·Oral Diseases·Julieta Saraí Becerra-RuizJuan Manuel Guzmán-Flores
Jun 3, 2021·International Journal of Molecular Sciences·Maisa Garcia-ArguinzonisTeresa Padro
Sep 14, 2021·Immunity, Inflammation and Disease·Mingde LiXingxing Huo

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Methods Mentioned

BETA
ELISAs
biopsies

Clinical Trials Mentioned

NCT02913248

Software Mentioned

GraphPad
SPSS
GraphPad Prism
‐ statistics

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