Complement split products c3a and c4a in chronic lyme disease

Scandinavian Journal of Immunology
Raphael B StrickerP C Giclas

Abstract

Complement split products C3a and C4a are reportedly elevated in patients with acute Lyme disease. We have now examined these immunologic markers in patients with chronic Lyme disease compared to appropriate disease controls. The study population consisted of 29 healthy controls, 445 patients with chronic Lyme disease, 11 patients with systemic lupus erythematosus (SLE) and six patients with AIDS. The Lyme disease patients were divided according to predominant musculoskeletal symptoms (324 patients) or predominant neurologic symptoms (121 patients). C3a and C4a levels were measured by radioimmunoassay. All patients with chronic Lyme disease and AIDS had normal C3a levels compared to controls, whereas patients with SLE had significantly increased levels of this marker. Patients with predominant musculoskeletal symptoms of Lyme disease and AIDS patients had significantly increased levels of C4a compared to either controls, patients with predominant neurologic symptoms of Lyme disease or SLE patients. Response to antibiotic therapy in chronic Lyme disease was associated with a significant decrease in the C4a level, whereas lack of response was associated with a significant increase in this marker. In contrast, AIDS patients had pe...Continue Reading

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Citations

Aug 4, 2010·Journal of Proteome Research·Jayme L WiederinPawel S Ciborowski
Jun 18, 2010·The Nurse Practitioner·Virginia Savely
Jan 1, 2010·Clinical, Cosmetic and Investigational Dermatology·Virginia R Savely, Raphael B Stricker
Jun 23, 2011·Infection and Drug Resistance·Raphael B Stricker, Lorraine Johnson
Oct 28, 2009·Journal of Women's Health·Raphael B Stricker, Lorraine Johnson
Nov 3, 2009·Clinical and Vaccine Immunology : CVI·Raphael B Stricker, Edward E Winger

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