Complement system activation in obstructive sleep apnea

Journal of Sleep Research
Peter HorvathAndras Bikov

Abstract

The complement system may play a role in the systemic inflammation characterising obstructive sleep apnea; however, this has not been investigated before. We aimed to study the involvement of effector complement elements in obstructive sleep apnea, namely C3a, C5a and SC5b-9. Venous blood was collected in 50 patients with obstructive sleep apnea and 26 control subjects in the evening and the following morning. Plasma complement proteins were analysed with ELISA. Complement factor levels were compared between the two groups and correlated with clinical variables. Plasma C3a concentration was elevated in obstructive sleep apnea both in the evening (84.1 [0-338.5] ng ml-1 ) and in the morning (85.5 [0-247.8] ng ml-1 ) compared with controls (30.3 [0-176.8] ng ml-1 and 36.3 [0-167.1] ng ml-1 , evening and morning, respectively, both p < 0.05). On the contrary, C5a and SC5b-9 levels were comparable between patients and controls at each time point (p > 0.05). There was no change in complement factors from evening to morning in either group (p > 0.05), except for C5a that decreased from evening to morning in obstructive sleep apnea (from 11.6 [1.6-47.4] ng ml-1 to 9.3 [0-46.4] ng ml-1 , p = 0.01). Elevated C3a levels were directly rel...Continue Reading

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Citations

Feb 7, 2019·Journal of Sleep Research·Andras BikovPal Maurovich-Horvat
Jan 27, 2019·International Journal of Molecular Sciences·Leila Kheirandish-Gozal, David Gozal
Sep 15, 2020·Frontiers in Cellular and Infection Microbiology·Pooja ShivshankarRick A Wetsel
May 17, 2019·Rejuvenation Research·Judit PákóAndrás Bikov
May 10, 2018·Lung·Laszlo KunosAndras Bikov
Nov 12, 2020·Scientific Reports·Martina MeszarosAndras Bikov
Oct 18, 2020·Clinical Physiology and Functional Imaging·Priyadarshini MishraManish Goyal
Mar 6, 2021·Biomarkers in Medicine·Martina MeszarosAndras Bikov
Feb 22, 2021·The Canadian Journal of Cardiology·Joshua M BockVirend K Somers
Apr 4, 2021·International Journal of Molecular Sciences·Andras BikovEsther Irene Schwarz
May 1, 2021·Journal of Clinical Medicine·Martina MeszarosAndras Bikov
Jul 14, 2021·Expert Review of Respiratory Medicine·Angelica TiotiuGuillermo Guidos

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