Complement System in Alcohol-Associated Liver Disease.

Immunology Letters
Lazara Elena Santiesteban-LoresLorena Bavia

Abstract

Innate immunity contributes effectively to the development of Alcohol-Associated liver disease (ALD). Particularly, human studies and murine models of ALD have shown that Complement activation plays an important role during the initial and later stages of ALD. The Complement System may contribute to the pathogenesis of this disease since it has been shown that ethanol-derived metabolic products activate the Complement cascade on liver membranes, leading to hepatocellular damage. However, studies evaluating the plasma levels of Complement proteins in ALD patients present contradictory results in some cases, and do not establish a well-marked role for each Complement component. The impairment of leukocyte chemoattractant activity observed in these patients may contribute to the susceptibility to bacterial infections in the latter stages of the disease. On the other hand, murine models of ALD have provided more detailed insights into the mechanisms that link the Complement System to the pathogenesis of the disease. It has been observed that Classical pathway can be activated via C1q binding to apoptotic cells in the liver and contributes to the development of hepatic inflammation. C3 contributes to the accumulation of triglyceride...Continue Reading

References

May 1, 1979·The Journal of Clinical Investigation·J Fierer, F Finley
Jan 1, 1977·Scandinavian Journal of Gastroenterology·G HusbyE Gjone
Aug 11, 1975·The American Journal of Medicine·D E Van EppsR C Williams
Jul 26, 1991·Journal of Immunological Methods·N G RyleyK A Fleming
Feb 1, 1990·Digestive Diseases and Sciences·R T EllisonJ Curd
Jan 1, 1989·International Immunology·B F MurphyA J d'Apice
Feb 1, 1988·Journal of Hepatology·J SuchF Vilardell
May 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B A Runyon
Sep 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R A RobbinsS I Rennard
Feb 15, 1985·The Biochemical Journal·A C Yeung LaiwahK Whaley
Jun 1, 1973·Gut·B J PotterE A Jones
Apr 6, 1972·The New England Journal of Medicine·A N DeMeo, B R Andersen
Oct 1, 1982·The Journal of Clinical Investigation·K M MorrisH R Colten
Jan 1, 1982·Clinical Immunology and Immunopathology·R L KaufmanF P Quismorio
Jan 1, 1982·Alcoholism, Clinical and Experimental Research·C S Lieber, L M DeCarli
Jan 1, 1981·International Archives of Allergy and Applied Immunology·F P QuismorioJ C Hoefs
Mar 1, 1982·American Journal of Clinical Pathology·M A SwerdlowT Horn
Mar 1, 1993·Journal of Clinical Pathology·N G RyleyK A Fleming
Dec 1, 1995·Alcoholism, Clinical and Experimental Research·G L BirdR S Williams
Jan 1, 1997·Clinical and Experimental Immunology·B P Morgan, P Gasque
Feb 11, 1999·The New England Journal of Medicine·C Gabay, I Kushner
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D MastellosJ D Lambris

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

World Journal of Gastroenterology : WJG
Arantza Lamas-PazFrancisco Javier Cubero
Clinics in Liver Disease
Sen HanSuthat Liangpunsakul
© 2021 Meta ULC. All rights reserved