PMID: 9646840Jul 1, 1998Paper

Complement system is not activated in primary biliary cirrhosis

Clinical Immunology and Immunopathology
M GardinaliM Podda

Abstract

There is controversial evidence suggesting that the classical pathway of complement system is chronically activated in primary biliary cirrhosis (PBC) and that complement activation may be important in development of bile duct injury. We have reevaluated this issue by measuring by-products of complement activation such as C4a, C3a, Bb, and terminal complement complexes (SC5b-9) in plasma of 44 PBC patients with sensitive methods not previously used to detect complement activation in this disease. Age-matched healthy women and patients with chronic hepatitis of different etiology were studied as controls. We found that PBC patients have normal C4a concentrations. This finding argues strongly against chronic classical pathway activation. Although a minor increase of C3a levels was observed in a minority of PBC patients, the C3a/C3 ratio, an index used to evaluate the extent of native protein conversion, was remarkably similar in all groups. Potentially lytic terminal complement complexes were not increased. PBC patients had normal Bb plasma levels, indicating that the alternative pathway is also not activated. C3 concentration was higher in PBC patients than in healthy subjects and in chronic hepatitis patients, particularly in t...Continue Reading

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Citations

Mar 11, 2010·Journal of Pediatric Gastroenterology and Nutrition·Hongtao WangRobert O Heuckeroth
Apr 24, 2014·European Journal of Clinical Investigation·Bo NilssonLars Lind
Jan 27, 2012·Biochemical and Biophysical Research Communications·Johannes SchmittAndreas Geier
Mar 10, 2015·Molecular Immunology·Andreea BarbuBo Nilsson
Apr 3, 2020·Autoimmunity Reviews·Maaike BiewengaLeendert A Trouw

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