Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention

Molecular Oral Microbiology
Dimitrios C MastellosJohn D Lambris

Abstract

There is increasing appreciation that complement dysregulation lies at the heart of numerous immune-mediated and inflammatory disorders. Complement inhibitors are therefore being evaluated as new therapeutic options in various clinical translation programs and the first clinically approved complement-targeted drugs have profoundly impacted the management of certain complement-mediated diseases. Among the many members of the intricate protein network of complement, the central component C3 represents a 'hot-spot' for complement-targeted therapeutic intervention. C3 modulates both innate and adaptive immune responses and is linked to diverse immunomodulatory systems and biological processes that affect human pathophysiology. Compelling evidence from preclinical disease models has shown that C3 interception may offer multiple benefits over existing therapies or even reveal novel therapeutic avenues in disorders that are not commonly regarded as complement-driven, such as periodontal disease. Using the clinically developed compstatin family of C3 inhibitors and periodontitis as illustrative examples, this review highlights emerging therapeutic concepts and developments in the design of C3-targeted drug candidates as novel immunothe...Continue Reading

References

May 1, 1978·Journal of Dental Research·P D TotoA Gargiulo
Jan 1, 1989·Journal of Clinical Periodontology·M R PattersN P Lang
Jun 1, 1987·Acta Odontologica Scandinavica·A A Nikolopoulou-PapaconstantinouT Kristoffersen
May 1, 1982·Journal of Periodontal Research·E T LallyP C Baehni
Nov 18, 2000·Advances in Immunology·M C PickeringM J Walport
Mar 12, 2005·Science·Jonathan L HainesMargaret A Pericak-Vance
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katarzyna PopadiakAnna M Blom
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hatice HasturkThomas E Van Dyke
Nov 9, 2007·Nature Biotechnology·Daniel Ricklin, John D Lambris
Oct 6, 2009·Molecular Immunology·Hongchang QuJohn D Lambris
Oct 16, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nirmal K BandaV Michael Holers
Oct 20, 2009·Trends in Immunology·Bo NilssonKristina Nilsson Ekdahl
Jan 28, 2010·Dental Clinics of North America·Joe W KrayerKeith L Kirkwood
Feb 16, 2010·Trends in Immunology·George Hajishengallis, John D Lambris
Feb 18, 2010·Science Signaling·Min WangGeorge Hajishengallis
Apr 10, 2010·Haematologica·Lucio LuzzattoRosario Notaro
Apr 29, 2010·Blood·Ioannis KourtzelisJohn D Lambris
Jul 27, 2010·Journal of Bacteriology·Floyd E DewhirstWilliam G Wade
Aug 20, 2010·Nature Immunology·Daniel RicklinJohn D Lambris
Dec 15, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shuang LiangGeorge Hajishengallis
Feb 23, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·You-Qiang WuJohn D Lambris
Feb 26, 2011·Nature Reviews. Immunology·George Hajishengallis, John D Lambris
Jun 29, 2011·Nature Reviews. Endocrinology·Evanthia Lalla, Panos N Papapanou
Jul 21, 2011·Advanced Drug Delivery Reviews·Kristina N EkdahlBo Nilsson
Nov 19, 2011·Journal of Clinical Periodontology·Georgios N Belibasakis, Nagihan Bostanci
Jan 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monika JuskoAnna M Blom
Mar 27, 2012·Nature Immunology·Mehmet A EskanGeorge Hajishengallis
Jul 4, 2012·Trends in Immunology·Claire L HarrisB Paul Morgan
Sep 1, 2012·Journal of Dental Research·P I EkeR J Genco
Sep 20, 2012·Advances in Experimental Medicine and Biology·Daniel Ricklin, John D Lambris

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Citations

Mar 30, 2016·Seminars in Immunology·George HajishengallisJohn D Lambris
Oct 27, 2016·Immunological Reviews·Daniel RicklinJohn D Lambris
Aug 2, 2017·Periodontology 2000·Jeffrey L EbersoleOctavio A Gonzalez
Oct 12, 2018·Nature Reviews. Microbiology·Richard J LamontGeorge Hajishengallis
Dec 30, 2017·Experimental and Therapeutic Medicine·Zhiping LiZhiping Xia
Apr 26, 2018·Journal of Immunology Research·Tilahun AlelignBeyene Petros
Jun 25, 2019·Frontiers in Immunology·Lygia Samartin Gonçalves LuchiniDenise V Tambourgi
Jan 17, 2020·FEBS Letters·Jillian M CarrDavid L Gordon
Aug 28, 2020·Periodontology 2000·George HajishengallisJohn D Lambris
Jul 28, 2017·Journal of Oral Microbiology·Ingar OlsenGeorge Hajishengallis
Oct 31, 2018·International Journal of Molecular Sciences·Yvonne MödingerAnita Ignatius
Nov 22, 2019·Frontiers in Immunology·Rebekka GröbnerJohannes Zschocke
Mar 28, 2019·Frontiers in Immunology·George HajishengallisJohn D Lambris
Mar 11, 2021·Periodontology 2000·George Hajishengallis, Richard J Lamont
Apr 24, 2019·Aging and Disease·Yuanyuan MaGuo-Yuan Yang
Oct 5, 2017·Journal of Medicinal Chemistry·Abishek IyerDavid P Fairlie

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