PMID: 7540013May 1, 1995Paper

Complementarity, specificity and the nature of epitopes and paratopes in multivalent interactions

Immunology Today
N S Greenspan, L J Cooper

Abstract

Structural elements of an antibody (Ab) or antigen (Ag) distant from the actual sites mediating contact between Ab and Ag can exert substantial influence on binding to, and discrimination among, multivalent targets. Consequently, multivalent molecules that express the same number of identical binding sites, but that differ in other structural features, can exhibit differences in their ability to discriminate between multivalent ligands. Here, Neil Greenspan and Laurence Cooper review evidence for these effects, and explore implications of the conclusion that effective specificity in multivalent interactions is not completely determined by the degree of complementarity between epitopes and paratopes.

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Citations

May 29, 1998·Immunological Reviews·G D WiensM B Rittenberg
May 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·George ThomRalph R Minter
Aug 20, 2002·The Journal of General Virology·P J Klasse, Q J Sattentau
May 20, 2011·The Journal of General Virology·Daniel L GlauserPhilip G Stevenson
Dec 27, 2011·Redox Report : Communications in Free Radical Research·Jasna OmerselBorut Božič
Oct 23, 2009·Annals of the New York Academy of Sciences·James A Shapiro
Apr 15, 2020·Viral Immunology·Neil S Greenspan
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcela TorresArturo Casadevall
Feb 15, 2001·The Journal of Allergy and Clinical Immunology·A Bufe
Jan 15, 2008·Trends in Immunology·Marcela Torres, Arturo Casadevall

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