Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

Biochemical and Biophysical Research Communications
T YamadaY Sakaki

Abstract

The human amyloid beta protein is a major component of brain amyloid found in patients with Alzheimer's disease. As an initial step to understand the biological function of its precursor protein, we have isolated cDNA for the mouse homolog of the human beta protein precursor. Comparison of the predicted amino acid sequence with that of human revealed a quite high degree of homology (96.8%), and the calculated evolutionary rate of the mRNA at amino acid substitution site was relatively low (0.1 x 10(-9)/site/year). The mRNA was abundant in brain and kidney, and also detected in other tissues at low level. These results indicated that this protein is highly conserved through mammalian evolution and may be involved in a basic biological process(es).

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·N K RobakisH M Wisniewski
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C L MastersK Beyreuther
Feb 1, 1986·Analytical Biochemistry·M Hattori, Y Sakaki
Aug 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T MiyataT Nishida

❮ Previous
Next ❯

Citations

May 1, 1994·Annals of Neurology·L S HigginsB Cordell
Jun 1, 1995·Journal of Neuroscience Research·L S GriffithB Schmitz
Jan 1, 1992·Journal of Molecular Neuroscience : MN·C A MarottaB Tate
Jan 1, 1991·Molecular Neurobiology·R N MartinsC L Masters
Nov 1, 2011·Experimental Brain Research·Collin Y Ewald, Chris Li
Jun 22, 2010·Journal of Molecular Neuroscience : MN·Thamil Mani Sivanandam, M K Thakur
Jan 1, 1992·Pharmacology & Therapeutics·A I BushC L Masters
Mar 20, 1992·Brain Research. Developmental Brain Research·C A Sherman, G A Higgins
Apr 1, 1989·Trends in Neurosciences·R E TanziJ F Gusella
Feb 17, 2000·Neurochemistry International·E J CoulsonC L Masters
Jan 6, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·T HarkanyC Nyakas
Feb 10, 2000·The Journal of Peptide Research : Official Journal of the American Peptide Society·S Zhang, J P Lee
Apr 24, 1999·Neuropathology and Applied Neurobiology·E Storey, R Cappai
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G A HigginsF H Gage
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S FisherM L Oster-Granite
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·I Daigle, C Li
Feb 1, 1992·Neuropathology and Applied Neurobiology·F CoriaJ Ghiso
Jul 1, 1993·The European Journal of Neuroscience·C SolàJ M Palacios
Jan 17, 1996·Annals of the New York Academy of Sciences·H ZhengL H Van der Ploeg
Nov 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Susan A AustinColin K Combs
Aug 20, 2010·International Journal of Alzheimer's Disease·Radmila Mileusnic, Steven Rose
Feb 22, 2001·Biochemical and Biophysical Research Communications·K KadoyamaT Yoshimoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.