Complementary effects of propranolol and nonoxynol-9 upon human sperm motility

Contraception
D R WhiteR J Aitken

Abstract

The inhibitory effects of nonoxynol-9, DL- and D-propranolol upon human sperm motility were determined in vitro. All three compounds were capable of causing complete cessation of sperm movement. However, greater efficacy was achieved using combinations of nonoxynol-9 and propranolol, suggesting a complementary interaction between these compounds. Investigations of the mechanism of action of propranolol revealed that an influx of calcium accompanied the loss of motility. However, since incubation in the absence of calcium enhanced the spermicidal effects of this compound, it was concluded that this calcium influx did not constitute the primary means by which motility was disrupted. Low doses of propranolol, which did not affect motility, were found to inhibit the capacity of human spermatozoa for sperm-oocyte fusion.

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Citations

May 20, 2009·In Vitro Cellular & Developmental Biology. Animal·Hehai WangCharles F Rosenkrans
Sep 1, 1996·Contraception·C H Lee
Jul 29, 2006·The Journal of Pharmacy and Pharmacology·Abhishek GulatiAnshu Gupta
Jan 2, 2009·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Vidya Iyer, S S Poddar
Jun 24, 2015·Nature Reviews. Urology·Mary K Samplaski, Ajay K Nangia
Feb 21, 2008·The Journal of Pharmacy and Pharmacology·Naveen KumarAshok Kumar Tiwary
Mar 14, 2018·Nature Reviews. Urology·Francesco Lotti, Mario Maggi
Sep 17, 2018·Environmental Science and Pollution Research International·Marco CapolupoMaria Laura Martín-Díaz

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