Complementary hydrogen bonding interaction triggered co-assembly of an amphiphilic peptide and an anti-tumor drug

Chemical Communications : Chem Comm
Hong ChengXian-Zheng Zhang

Abstract

We report a new tumor-targeting amphiphilic peptide that can form complementary hydrogen bonds with anti-tumor drug methotrexate (MTX), leading to reversible self-assembled morphology transition from loose micelles to densely packed nanorods or nanofibers. The MTX loaded nanorods can target tumor cells and show more than 2-fold higher cytotoxicity (IC50 = 0.38 mg L(-1)) than that towards normal cells (IC50 = 0.89 mg L(-1)).

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Citations

Aug 5, 2016·Chemical Society Reviews·Juan WangXuehai Yan
Oct 27, 2017·Nanoscale Research Letters·Jinyu WangPeizhi Zhu
Dec 21, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Mehdi Soleymani-GoloujehHadi Valizadeh
May 1, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zheng Lian, Tianjiao Ji
Nov 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kai HanXian-Zheng Zhang
Oct 21, 2020·Advanced Drug Delivery Reviews·Ke LiXian-Zheng Zhang
May 29, 2021·Chemical Communications : Chem Comm·Yan JiangSi-Yong Qin
May 2, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Jing ZhangShiyong Zhang

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