The projections from the amygdala and hippocampus (including subiculum and presubiculum) to prefrontal cortex were compared using anterograde tracers injected into macaque monkeys (Macaca fascicularis, Macaca mulatta). Almost all prefrontal areas were found to receive some amygdala inputs. These connections, which predominantly arose from the intermediate and magnocellular basal nucleus, were particularly dense in parts of the medial and orbital prefrontal cortex. Contralateral inputs were not, however, observed. The hippocampal projections to prefrontal areas were far more restricted, being confined to the ipsilateral medial and orbital prefrontal cortex (within areas 11, 13, 14, 24a, 32, and 25). These hippocampal projections principally arose from the subiculum, with the fornix providing the sole route. Thus, while the lateral prefrontal cortex essentially receives only amygdala inputs, the orbital prefrontal cortex receives both amygdala and hippocampal inputs, though these typically target different areas. Only in medial prefrontal cortex do direct inputs from both structures terminate in common sites. But, even when convergence occurs within an area, the projections predominantly terminate in different lamina (hippocampal...Continue Reading
Amygdaloid projections to prefrontal granular cortex in rhesus monkey demonstrated with horseradish peroxidase
Distribution of hippocampal CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of Phaseolus vulgaris-leucoagglutinin
Projections from the amygdala to basoventral and mediodorsal prefrontal regions in the rhesus monkey
A comparison of the efferents of the amygdala and the hippocampal formation in the rhesus monkey: I. Convergence in the entorhinal, prorhinal, and perirhinal cortices
Comparison of the efferents of the amygdala and the hippocampal formation in the rhesus monkey: II. Reciprocal and non-reciprocal connections
A comparison between the connections of the amygdala and hippocampus with the basal forebrain in the macaque
Effects of fimbria-fornix transection and ganglioside treatments on histochemical staining for glucose-6-phosphate dehydrogenase in the lateral septum
The afferent input to the magnocellular division of the mediodorsal thalamic nucleus in the monkey, Macaca fascicularis
Visual recognition in monkeys: effects of separate vs. combined transection of fornix and amygdalofugal pathways
Interhemispheric pathways of the hippocampal formation, presubiculum, and entorhinal and posterior parahippocampal cortices in the rhesus monkey: the structure and organization of the hippocampal commissures
Dual pathways connecting the dorsolateral prefrontal cortex with the hippocampal formation and parahippocampal cortex in the rhesus monkey
Stereotaxic surgery under X-ray guidance in the rhesus monkey, with special reference to the amygdala
Topographically specific hippocampal projections target functionally distinct prefrontal areas in the rhesus monkey
Organization of direct hippocampal efferent projections to the cerebral cortex of the rhesus monkey: projections from CA1, prosubiculum, and subiculum to the temporal lobe
Cortical projections of the non-entorhinal hippocampal formation in the cynomolgus monkey (Macaca fascicularis)
Comparison of hippocampal, amygdala, and perirhinal projections to the nucleus accumbens: combined anterograde and retrograde tracing study in the Macaque brain
Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey
Proton magnetic resonance spectroscopy (1H MRS) in schizophrenia: investigation of the right and left hippocampus, thalamus, and prefrontal cortex
Complementary subicular pathways to the anterior thalamic nuclei and mammillary bodies in the rat and macaque monkey brain
Impairment on a self-ordered working memory task in patients with early-acquired hippocampal atrophy
Off to a Good Start: The Early Development of the Neural Substrates Underlying Visual Working Memory
Hippocampal Interaction With Area 25, but not Area 32, Regulates Marmoset Approach-Avoidance Behavior.
Fornix Structural Connectivity and Allostatic Load: Empirical Evidence From Schizophrenia Patients and Healthy Controls
Translating Fear Circuitry: Amygdala Projections to Subgenual and Perigenual Anterior Cingulate in the Macaque.
The Role of Hippocampal Functional Connectivity on Multisystem Subclinical Abnormalities in Schizophrenia.
Distribution and overlap of entorhinal, premotor, and amygdalar connections in the monkey anterior cingulate cortex.
The Role of Hippocampal-Ventromedial Prefrontal Cortex Neural Dynamics in Building Mental Representations.
The Inverse Relationship between the Microstructural Variability of Amygdala-Prefrontal Pathways and Trait Anxiety Is Moderated by Sex
Trajectory of hippocampal fibres to the contralateral anterior thalamus and mammillary bodies in rats, mice, and macaque monkeys.
Topographic separation of fornical fibers associated with the anterior and posterior hippocampus in the human brain: An MRI-diffusion study
Laminar Pattern of Projections Indicates the Hierarchical Organization of the Anterior Cingulate-Temporal Lobe Emotion System
The macaque anterior cingulate cortex translates counterfactual choice value into actual behavioral change.
Altered hippocampal-prefrontal functional network integrity in adult macaque monkeys with neonatal hippocampal lesions.
Brain Connectivity Changes after Osteopathic Manipulative Treatment: A Randomized Manual Placebo-Controlled Trial
Repetitive transcranial magnetic stimulation restores altered functional connectivity of central poststroke pain model monkeys.
Corticolimbic circuit structure moderates an association between early life stress and later trait anxiety
Seizure frequency is associated with effective connectivity of the hippocampal-diencephalic-cingulate in epilepsy with unilateral mesial temporal sclerosis
Evidence in primates supporting the use of chemogenetics for the treatment of human refractory neuropsychiatric disorders.
Functional Contribution of the Medial Prefrontal Circuitry in Major Depressive Disorder and Stress-Induced Depressive-Like Behaviors.
Amygdala: Sensory Processes
Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.
Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.
Amygdala and Midbrain Dopamine
The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.