Complementary Patterns of Direct Amygdala and Hippocampal Projections to the Macaque Prefrontal Cortex

Cerebral Cortex
John P AggletonRichard C Saunders


The projections from the amygdala and hippocampus (including subiculum and presubiculum) to prefrontal cortex were compared using anterograde tracers injected into macaque monkeys (Macaca fascicularis, Macaca mulatta). Almost all prefrontal areas were found to receive some amygdala inputs. These connections, which predominantly arose from the intermediate and magnocellular basal nucleus, were particularly dense in parts of the medial and orbital prefrontal cortex. Contralateral inputs were not, however, observed. The hippocampal projections to prefrontal areas were far more restricted, being confined to the ipsilateral medial and orbital prefrontal cortex (within areas 11, 13, 14, 24a, 32, and 25). These hippocampal projections principally arose from the subiculum, with the fornix providing the sole route. Thus, while the lateral prefrontal cortex essentially receives only amygdala inputs, the orbital prefrontal cortex receives both amygdala and hippocampal inputs, though these typically target different areas. Only in medial prefrontal cortex do direct inputs from both structures terminate in common sites. But, even when convergence occurs within an area, the projections predominantly terminate in different lamina (hippocampal...Continue Reading


Sep 1, 1977·The Journal of Comparative Neurology·C E Poletti, G Creswell
Sep 28, 1977·Experimental Brain Research·J Kievit, H G Kuypers
Feb 1, 1978·The Journal of Comparative Neurology·B H TurnerM Mishkin
Oct 8, 1976·Brain Research·A G Herzog, G W Van Hoesen
Sep 15, 1992·The Journal of Comparative Neurology·R J MorecraftM M Mesulam
Jan 1, 1991·Cerebral Cortex·D J Felleman, D C Van Essen
Jun 1, 1991·Brain : a Journal of Neurology·E A GaffanJ R Hodges
Oct 22, 1990·The Journal of Comparative Neurology·H Barbas, J De Olmos
Jan 15, 1986·The Journal of Comparative Neurology·J P AggletonM Mishkin
May 1, 1987·Neurobiology of Aging·R M Booze, J N Davis
Jan 1, 1986·Experimental Brain Research·J P Aggleton
Jan 1, 1985·Experimental Brain Research·J P Aggleton
May 1, 1981·The Journal of Comparative Neurology·L J PorrinoP S Goldman-Rakic
Jan 1, 1984·The Journal of Comparative Neurology·J P Aggleton, M Mishkin
Dec 20, 1984·The Journal of Comparative Neurology·D G Amaral, J L Price
Apr 10, 1984·The Journal of Comparative Neurology·D G AmaralW M Cowan
Jan 1, 1981·Experimental Brain Research·J P Aggleton, R E Passingham
Aug 15, 1994·The Journal of Comparative Neurology·S T Carmichael, J L Price
Dec 25, 1995·The Journal of Comparative Neurology·S T Carmichael, J L Price
Aug 15, 1998·Journal of Neurophysiology·M ColomboC G Gross
Jun 26, 1999·The European Journal of Neuroscience·R MorrisD N Pandya
Jul 23, 1999·Annals of the New York Academy of Sciences·J L Price
Jan 15, 2000·Science·J L McGaugh
Sep 19, 2000·The Journal of Comparative Neurology·Y Kobayashi, D G Amaral
Apr 3, 2001·Annual Review of Neuroscience·E K Miller, J D Cohen
May 7, 2002·The Journal of Comparative Neurology·Pierre LavenexDavid G Amaral
Aug 2, 2003·Nature Reviews. Neuroscience·Jon S Simons, Hugo J Spiers
Feb 1, 1954·Journal of Neurology, Neurosurgery, and Psychiatry·H M DAITZ, T P POWELL
Mar 26, 2005·The Journal of Comparative Neurology·Brent A VogtGeorge Bush

❮ Previous
Next ❯


Feb 13, 2016·Nature Reviews. Neuroscience·Peter Zeidman, Eleanor A Maguire
Mar 1, 2016·Current Addiction Reports·Theresa H McKimCharlotte A Boettiger
Jun 30, 2015·The European Journal of Neuroscience·Andrew R AbelaYogita Chudasama
Feb 9, 2016·The European Journal of Neuroscience·Kat ChristiansenJohn P Aggleton
Jun 12, 2016·Developmental Cognitive Neuroscience·Sharon GevaFaraneh Vargha-Khadem
Aug 29, 2016·Journal of Alzheimer's Disease : JAD·Eun Hyun SeoIl Han Choo
Sep 3, 2016·Frontiers in Systems Neuroscience·Allison FitchZsuzsa Kaldy
Sep 26, 2017·Brain and Neuroscience Advances·Emma J BubbJohn P Aggleton
Jun 8, 2019·The Journal of Comparative Neurology·Cynthia M SchumannDavid G Amaral
Apr 9, 2020·Brain Connectivity·Hamid Soltani ZangbarParviz Shahabi
Jul 18, 2020·The Journal of Comparative Neurology·Samantha M CalderazzoMaria Medalla
Sep 29, 2020·Journal of Cognitive Neuroscience·Anna M MonkEleanor A Maguire
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jocelyne Bachevalier
Jun 23, 2020·Brain Connectivity·Susan L BenearIngrid R Olson
Jan 29, 2019·Frontiers in Systems Neuroscience·Naomi HartoppMichael J O'Sullivan
Mar 29, 2020·Brain and Neuroscience Advances·Bethany M CoadClaudia Metzler-Baddeley
Apr 17, 2019·Nature Neuroscience·Elsa F FouragnanMatthew F S Rushworth
Mar 25, 2020·Science Advances·Hannah KiesowDanilo Bzdok
Oct 24, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Dongchul ShinDuck-Joo Rhie
Dec 16, 2020·Nature Communications·R Nathan SprengDanilo Bzdok
Dec 15, 2020·Human Brain Mapping·Samuel C BerryThomas M Lancaster
Apr 8, 2020·Neuropsychologia·Angharad N WilliamsCarl J Hodgetts
Sep 28, 2017·Current Opinion in Psychology·Nim Tottenham, Laurel J Gabard-Durnam
Apr 26, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Patrick H RoseboomNed H Kalin
Jun 4, 2021·The American Journal of Psychiatry·Daniel S PineElisabeth A Murray
Jul 4, 2021·Brain Structure & Function·Nicola Palomero-Gallagher, Katrin Amunts

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.