Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation

Annals of Neurology
Fraser J SimSteven A Goldmanm

Abstract

Glial progenitor cells are abundant in adult human white matter. This study was designed to identify signaling pathways regulating their self-renewal and fate. We compared the transcriptional profiles of freshly sorted adult human white matter progenitor cells (WMPCs), purified by A2B5-based immunomagnetic sorting, with those of the white matter from which they derived. We identified 132 genes differentially expressed by WMPCs; these included principal components of five receptor-defined signaling pathways, represented by platelet derived growth factor receptor alpha (PDGFRA) and type 3 fibroblast growth factor receptor (FGFR3), receptor tyrosine phosphatase-beta/zeta (RTPZ), notch, and syndecan3. WMPCs also differentially expressed the bone morphogenetic protein 4 (BMP4) inhibitors neuralin and BAMBI (BMP and activin membrane-bound inhibitor), suggesting tonic defense against BMP signaling. Differential overexpression of RTPZ was accompanied by that of its modulators pleiotrophin, NrCAM, tenascin, and the chondroitin sulfate proteoglycans, suggesting the importance of RTPZ signaling to WMPCs. When exposed to the RTPZ inhibitor bpV(phen), or lentiviral-shRNAi against RTPZ, WMPCs differentiated as oligodendrocytes. Conversely, w...Continue Reading

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Citations

Mar 1, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Elif G SozmenS Thomas Carmichael
Oct 8, 2009·Neuron Glia Biology·Fraser J SimSteven A Goldman
Sep 30, 2009·Neuron Glia Biology·Susan M Staugaitis, Bruce D Trapp
Dec 7, 2010·Nature Neuroscience·Jeffrey K HuangRobin J M Franklin
Oct 28, 2011·Nature Neuroscience·Steven A Goldman, Zhuoxun Chen
Sep 19, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jean E Merrill
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Smaragda LamprianouSheila Harroch
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Jan 14, 2011·Cerebral Cortex·Philip GaughwinPatrik Brundin
Dec 15, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaowei LiXuejun Wen
Nov 1, 2012·Science·Steven A GoldmanMartha S Windrem
Sep 22, 2007·The Journal of Clinical Investigation·Sung-Rae ChoSteven A Goldman
May 3, 2013·PloS One·Bi-Sen DingAdília Hormigo
Oct 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Crystal R McClainSteven A Goldman
Mar 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiomara PedrePatrizia Casaccia
May 11, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Muzhou WuPatrizia Casaccia
Mar 29, 2014·Nature Neuroscience·Steven A Goldman, Joana Osorio
Jul 2, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jing WangFraser J Sim
Jan 19, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Anna J KhalajSeema K Tiwari-Woodruff
Aug 20, 2010·Journal of Neuropathology and Experimental Neurology·Qiao Ling CuiGuillermina Almazan
Jun 23, 2009·Hormones and Behavior·Charlotte C BruceRobin J M Franklin
Sep 26, 2015·Cell·Alex A PollenArnold R Kriegstein
Apr 24, 2007·Progress in Neurobiology·Jessica CarmenMark P Mattson
Jan 25, 2007·Neurosurgery Clinics of North America·H Michael Keyoung, Steven A Goldman
Nov 8, 2008·Annals of the New York Academy of Sciences·Tamir Ben-Hur, Steven A Goldman
Apr 3, 2008·The European Journal of Neuroscience·Tetsuya ImuraShinji Fushiki
Mar 24, 2016·Experimental Neurology·Karen C DietzFraser J Sim
Dec 21, 2011·Molecular and Cellular Neurosciences·Takeshi Sakurai
Apr 23, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Oscar GomezEduardo Molina-Holgado

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