Complementary regional heterogeneity information from COPD patients obtained using oxygen-enhanced MRI and chest CT

PloS One
Yoshinori FuseyaToyohiro Hirai

Abstract

The heterogeneous distribution of emphysema is a key feature of chronic obstructive pulmonary disease (COPD) patients that typically is evaluated using high-resolution chest computed tomography (HRCT). Oxygen-enhanced pulmonary magnetic resonance imaging (OEMRI) is a new method to obtain information regarding regional ventilation, diffusion, and perfusion in the lung without radiation exposure. We aimed to compare OEMRI with HRCT for the assessment of heterogeneity in COPD patients. Forty patients with stable COPD underwent quantitative HRCT, OEMRI, and pulmonary function tests, including arterial blood gas analysis. OEMRI was also performed on nine healthy control subjects. We measured the severity of emphysema (percent low attenuation volume; LAV%) in whole lungs and the standard deviations (SDs) of the LAV% values of 10 isovolumetric partitions (SD-LAV) as an index of cranial-caudal heterogeneity. Similarly, relative enhancement ratios of oxygen (RERs) in whole lungs from OEMRI and SD-RER were analyzed. COPD patients showed a lower mean RER than control subjects (12.6% vs 22.0%, p<0.01). The regional heterogeneity of the RERs was not always consistent with the LAV distribution. Both the HRCT (LAV% and SD-LAV) and the OEMRI (...Continue Reading

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Citations

Apr 17, 2019·Clinical and Translational Medicine·Lukasz A MycJulien Dimastromatteo
Apr 17, 2020·American Journal of Respiratory and Critical Care Medicine·Adrienne E Campbell-Washburn
Feb 3, 2021·The British Journal of Radiology·Yoshiharu OhnoHiroshi Toyama
Apr 9, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ilyes BenlalaGael Dournes
May 7, 2021·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Yumi TanakaHiroshi Toyama

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Methods Mentioned

BETA
imaging techniques
imaging technique

Software Mentioned

COPDGene
JMP

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