PMID: 7015347Mar 1, 1981Paper

Complementation of the plaque-forming cell responses of T-cell-deficient nude mice by a T-cell hybridoma

Proceedings of the National Academy of Sciences of the United States of America
M L Misfeldt, E E Hanna

Abstract

Spleen cells from NFR/N mice primed with carrier rabbit erythrocytes were passed through nylon wool and fused with cells from the AKR T-cell lymphoma BW5147 in order to construct functional T-cell hybridomas. Several hybrids have been obtained. One of the cloned hybrids possesses a marked capacity to functionally complement the T-cell-dependent hapten-specific plaque-forming cell responses of NFR/N nude mice to the trinitrophenyl group. The hybrids carry the Thy 1 marker of the immune parent, express the Lyt 1 surface marker, possess Fc receptors at their surface, and express an Ig heavy-chain variable region determinant at their surfaces as detected by anti-VH MOPC 315 antiserum.

References

Oct 1, 1977·European Journal of Immunology·G J Hämmerling
Aug 3, 1978·Nature·S KontiainenM Feldmann
Mar 10, 1971·Nature: New Biology·C P StannersH Green
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt
Jan 1, 1980·European Journal of Immunology·L A HerzenbergL A Herzenberg

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Citations

Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J LeW Prensky

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