PMID: 3094014Oct 1, 1986Paper

Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: close homology to the serine antiproteases

Proceedings of the National Academy of Sciences of the United States of America
I L FlinkE Morkin


Antibodies directed against thyroxine-binding globulin (TBG) have been used to screen a human liver lambda gt11 expression library. A 1.46-kilobase clone was identified which encodes nearly the complete amino acid sequence, beginning at amino acid 17 of the mature protein. To complete the protein sequence, the cDNA clone was used to identify a genomic clone coding for TBG in a human X chromosome library. The overlapping recombinant clones contained an open reading frame coding for 415 amino acids followed by a polyadenylylation signal (AATAAA) located 275 nucleotides from a TAG termination codon. Beginning at residue 21, the deduced amino acid sequence agrees closely with the known NH2-terminal sequence of the mature peptide. The preceding 20 amino acid residues are hydrophobic in character and presumably represent a leader sequence. Four glycosylation sites were identified, corresponding to the number determined for the purified protein. DNA blot hybridization revealed a single-copy gene, which by chromosomal analysis was found to be located on the long arm of the X chromosome. Unexpectedly, the nucleotide sequence of TBG is closely homologous to those encoding the plasma serine antiproteases alpha 1-antichymotrypsin and alpha...Continue Reading


Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Dec 21, 1977·Biochemical and Biophysical Research Communications·S Y Cheng
Sep 16, 1976·Nature·N J Proudfoot, G G Brownlee
Jan 1, 1983·Annual Review of Biochemistry·J Travis, G S Salvesen
Jan 24, 1981·Nucleic Acids Research·J MessingP H Seeburg
Dec 20, 1982·Nucleic Acids Research·S C BockR M Lawn
Nov 18, 1983·Science·R A Young, R W Davis
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T ChandraS L Woo
Apr 1, 1981·The Journal of Clinical Endocrinology and Metabolism·R GärtnerP C Scriba
Jan 1, 1981·Annual Review of Biochemistry·R Breathnach, P Chambon
Jul 31, 1980·Biochemical and Biophysical Research Communications·L T Hunt, M O Dayhoff
Jan 1, 1981·Annual Review of Biochemistry·G Kreil
Jan 1, 1959·The Journal of Clinical Endocrinology and Metabolism·S TANAKA, P STARR


Jan 9, 2001·Archives of Biochemistry and Biophysics·S A SudaP A Patston
Jan 1, 1989·Carlsberg Research Communications·R Lundgard, B Svensson
Sep 2, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Deborah MannavolaPaolo Beck-Peccoz
Jan 1, 1989·Journal of Steroid Biochemistry·J P MornonJ P Raynaud
Dec 14, 1993·Biochimica Et Biophysica Acta·M T AkbariD B Ramsden
Mar 1, 1993·Molecular and Cellular Endocrinology·S SakataM Z Atassi
Dec 1, 1993·Molecular and Cellular Endocrinology·A Tsykin, G Schreiber
Oct 1, 1995·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Z Liang, K Söderhäll
Jul 26, 1991·Biochimica Et Biophysica Acta·L SavuI L Flink
Feb 19, 2002·Molecular and Cellular Endocrinology·O E JanssenRalf Einspanier
Feb 1, 1997·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·G Schreiber, S J Richardson
Feb 11, 1999·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·J L Hunt, P Licht
May 13, 1999·Nutrition·Y Ingenbleek, L Bernstein
Nov 1, 1988·Baillière's Clinical Endocrinology and Metabolism·J A Franklyn
Nov 28, 2001·European Journal of Biochemistry·I JerabekM Geiger
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A W StephensC H Hirs
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G L HammondC W Bardin
Feb 18, 2011·The Journal of Biological Chemistry·Xiaoqiang QiAiwu Zhou
Mar 1, 1989·DNA·I GaillardP Corvol
Jan 1, 1990·Thyroid : Official Journal of the American Thyroid Association·G C Schussler
Jan 1, 1992·Thyroid : Official Journal of the American Thyroid Association·L Bartalena, J Robbins
Mar 16, 2000·Thyroid : Official Journal of the American Thyroid Association·G C Schussler
Sep 25, 2007·Thyroid : Official Journal of the American Thyroid Association·Katarzyna LackaJan K Lacki
Apr 1, 1993·Clinical Endocrinology·A F BristowM B Pepys
Jun 21, 2013·The Journal of Clinical Endocrinology and Metabolism·Wee Lee ChanRandy J Read
Apr 1, 1990·Journal of Endocrinological Investigation·M R WaltzS Refetoff
Mar 9, 2002·Journal of Endocrinological Investigation·S BenvengaF Trimarchi
Dec 3, 2014·Journal of the Chinese Medical Association : JCMA·Chun-Jui Huang, Tjin-Shing Jap
Sep 11, 2012·Journal of Insect Physiology·Melissa M GulleyKristin Michel
Jul 27, 1999·The Journal of Investigative Dermatology·M KrebsB R Binder
Nov 23, 2006·Annals of the New York Academy of Sciences·R Thomas Zoeller
Aug 14, 1987·Biochemical and Biophysical Research Communications·K YamauchiR Horiuchi
Mar 1, 1992·Trends in Endocrinology and Metabolism : TEM·O E JanssenS Refetoff
Mar 15, 2003·Risk Analysis : an Official Publication of the Society for Risk Analysis·R Thomas Zoeller
Apr 18, 2006·Cell·Noriaki KondoTakashi Ohtsu
Dec 23, 2014·Biochemical and Biophysical Research Communications·Peng-Chao GuoPing Zhao
Jul 15, 2016·Pharmacology & Therapeutics·David HenleyR W Carrell
Nov 9, 2000·European Journal of Immunology·J K FrazerV Pascual
Jan 28, 2004·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Neepa Y ChoksiMichael Shelby
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·S BenvengaJ Robbins
Mar 17, 2007·Critical Reviews in Toxicology·R Thomas ZoellerRochelle W Tyl
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Rosa M CalvoGabriella Morreale de Escobar
Jan 1, 1992·Animal Genetics·V HanrahanD F Hill
Dec 1, 1989·Journal of Endocrinological Investigation·L J DeGrootE Macchia
Apr 9, 2020·Journal of Endocrinological Investigation·L-D ChenL Li
May 1, 1993·Journal of Endocrinological Investigation·L Bartalena
Feb 9, 2021·Molecular Genetics & Genomic Medicine·Yanlan FangLi Liang
Nov 24, 1995·The Journal of Biological Chemistry·O E JanssenP C Scriba

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