PMID: 6167990Jun 1, 1981Paper

Complete amino acid sequence of variable domains from two monoclonal human anti-gamma globulins of the Wa cross-idiotypic group: suggestion that the J segments are involved in the structural correlate of the idiotype

Proceedings of the National Academy of Sciences of the United States of America
D W Andrews, J D Capra

Abstract

The complete amino acid sequences of the variable regions of two human IgM anti-gamma globulins are reported. The two proteins, Sie and Wol, share idiotypic determinants that are distinct from those shared by the two previously sequenced IgM anti-gamma globulins, Lay and Pom [Capra, J. D. & Kehoe, J. M. (1974) Proc. Natl. Acad. Sci. USA 71, 4032-4036; Klapper, D. G. & Capra, J. D. (1976) Ann. Immunol. (Inst. Pasteur) 127C, 261-271.] In contrast to Lay and Pom, Sie and Wol have very little homology in the complementarity-determining hypervariable regions of either their light or heavy polypeptide chains. However, there are only two amino acid differences in the framework portions of the light chains, and the J segments of both chains are homologous. These data suggest that the predominant idiotypic determinant in this cross-idiotypic system may be different than in the Po group and may be either related to their light chain framework structures or to the amino acid sequence in the J segments of these molecules.

References

Mar 15, 1978·Biochemical and Biophysical Research Communications·D N Podell, G N Abraham
Mar 1, 1978·Analytical Biochemistry·D G KlapperJ D Capra
Feb 1, 1973·The Journal of Experimental Medicine·H G KunkelJ D Capra
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J D Capra, J M Kehoe
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R J PoljakF Saul
Jan 1, 1974·The Journal of Experimental Medicine·H G KunkelJ D Capra
Jan 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J D CapraH G Kunkel
Jan 1, 1955·The Journal of Experimental Medicine·R J SLATERH G KUNKEL

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Citations

Jan 1, 1988·Springer Seminars in Immunopathology·V Agnello
Jan 1, 1983·Springer Seminars in Immunopathology·I M RoittP M Lydyard
Jan 1, 1988·Springer Seminars in Immunopathology·A C Wang
Jan 1, 1988·Springer Seminars in Immunopathology·P P ChenD A Carson
Jan 1, 1988·Springer Seminars in Immunopathology·C A Bona
Apr 1, 1997·Clinical Reviews in Allergy & Immunology·F Dammacco, D Sansonno
Nov 1, 1988·Annales De L'Institut Pasteur. Immunology·R MakarJ D Capra
Jan 1, 1994·Advances in Neuroimmunology·A K Lefvert
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P P ChenD A Carson
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P P ChenD A Carson
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T J KippsD A Carson
Dec 1, 1986·The Journal of Experimental Medicine·V RadouxD A Carson
May 1, 1996·The Journal of Clinical Investigation·E H SassoT J Kipps
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·M WelschofG Opelz
Aug 1, 1989·Journal of Autoimmunity·F SilvestrisR C Williams
Jan 1, 1983·Annals of the New York Academy of Sciences·H G KunkelB Pernis
Feb 1, 1986·Scandinavian Journal of Immunology·D N PosnettH G Kunkel

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