Complete and Partial Lecithin:Cholesterol Acyltransferase Deficiency Is Differentially Associated With Atherosclerosis

Circulation
Federico OldoniLaura Calabresi

Abstract

Lecithin:cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma. Its role in the supposed protection from atherogenesis remains unclear because mutations in LCAT causing fish-eye disease (FED) or familial LCAT deficiency (FLD) have been reported to be associated with more or instead less carotid atherosclerosis, respectively. This discrepancy may be associated with the loss of cholesterol esterification on only apolipoprotein AI (FED) or on both apolipoprotein AI- and apolipoprotein B-containing lipoproteins (FLD), an aspect that has thus far not been investigated. Seventy-four heterozygotes for LCAT mutations recruited from Italy and the Netherlands were assigned to FLD (n=33) or FED (n=41) groups and compared with 280 control subjects. Subclinical atherosclerosis was assessed with carotid intima-media thickness. Compared with control subjects, total cholesterol was lower by 16% (-32.9 mg/dL) and 7% (-14.9 mg/dL) and high-density lipoprotein cholesterol was lower by 29% (-16.7 mg/dL) and 36% (-20.7 mg/dL) in the FLD and FED groups, respectively. Subjects with FLD displayed a significant 18% lower low-density lipoprotein cholesterol compared with subjects with FED (101.9±35.0 versus 123.6±47...Continue Reading

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Citations

Oct 20, 2018·Journal of Lipid Research·Andrew S GellerErnst J Schaefer
Feb 6, 2019·Current Opinion in Lipidology·Ernst J SchaeferGregory Endress
Mar 9, 2019·International Journal of Molecular Sciences·Shi-Hui LawLiang-Yin Ke
May 29, 2019·Current Opinion in Lipidology·Andreas Sourlas, Constantine E Kosmas
Feb 20, 2020·Current Opinion in Lipidology·Lita A FreemanAlan T Remaley
Nov 24, 2019·Journal of Clinical Pathology·Raashda A Sulaiman
Jul 4, 2020·Current Opinion in Lipidology·Chiara Pavanello, Laura Calabresi
Oct 2, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Mengmeng GuoXunde Xian
Nov 7, 2019·Der Internist·Arnold von Eckardstein
Sep 28, 2020·The Journal of Pharmacology and Experimental Therapeutics·Chiara PavanelloLaura Calabresi
Apr 20, 2021·Journal of Atherosclerosis and Thrombosis·Masayuki KurodaMariko Harada-Shiba
May 14, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Mengmeng GuoXunde Xian
Jun 8, 2021·Circulation·Anand RohatgiKerry-Anne Rye
Jul 15, 2021·Lipids in Health and Disease·Roopa MehtaCarlos A Aguilar-Salinas
Oct 13, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Emilie Westerlin KjeldsenRuth Frikke-Schmidt
Nov 19, 2021·Acta Clinica Belgica·Nuria Goñi RosJosé Puzo Foncillas

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