Complete androgen insensitivity: the role of the surgeon

The Journal of Urology
J Todd PurvesJ P Gearhart

Abstract

This is a retrospective series of the surgical management of complete androgen insensitivity at a single institution. The records of 16 patients 4 to 63 years old with complete androgen insensitivity were extracted from an institutionally approved database. We determined whether each patient underwent vaginoplasty, age at vaginoplasty, vaginal depth before vaginoplasty, age at gonadectomy and whether the patient was sexually active. These data were pooled with those from a prior study at our institution to yield a total of 29 patients. All patients had undergone gonadectomy with no evidence of malignancy in any pathology specimens. Of the 27 patients in whom the date of surgery was known 20 underwent surgery in late adolescence/adulthood, while 7 had the testes removed in childhood. Of the 29 patients 11 (38%) have undergone vaginal reconstruction. Average vaginal depth in postpubertal patients without reconstruction was 6.6 cm (range 1.5 to 10). Preoperative vaginal depth in patients with was between 2 and 4 cm. Ten postpubertal patients have undergone vaginoplasty and 7 (70%) are sexually active. Of the postpubertal patients 15 have not undergone vaginoplasty, of whom 12 (80%) are sexually active. A delayed approach to gonade...Continue Reading

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Citations

Jan 21, 2016·Nature Reviews. Urology·Alice FaureYves Heloury
Jan 2, 2013·Journal of Pediatric Urology·Eric Z MassanyiJohn P Gearhart
Jun 16, 2012·Lancet·Ieuan A HughesJane MacDougall
Mar 29, 2011·The Journal of Urology·Riitta FagerholmSeppo Taskinen
Nov 4, 2009·Journal of Pediatric and Adolescent Gynecology·Lisa Allen
Aug 30, 2014·The Journal of Obstetrics and Gynaecology Research·Zhou WangYue-min Xu
Dec 29, 2013·Gynecologic Oncology Case Reports·Hiroshi TsubamotoHideaki Sawai
Mar 10, 2010·Neonatal Network : NN·Robin L Snyder
Jun 6, 2014·Human Reproduction Update·Nina CallensMartine Cools
Sep 20, 2018·The New England Journal of Medicine·Christos CoutifarisEsther Oliva
Mar 3, 2012·Clinical and Experimental Reproductive Medicine·Hyun-Ok KimByung-Moon Kang
May 29, 2014·Hernia : the Journal of Hernias and Abdominal Wall Surgery·Udit GiborBoris Kirshtein
Nov 1, 2009·Expert Review of Endocrinology & Metabolism·Alaa CheikhelardClaire Nihoul-Fekete
Apr 6, 2021·Annals of Pediatric Endocrinology & Metabolism·Beatriz Amstalden BarrosGil Guerra-Junior
Jul 2, 2021·Systems Biology in Reproductive Medicine·Hossein HosseiniradYousef Sadeghi
Jun 25, 2019·Journal of Pediatric and Adolescent Gynecology·Erica M WeidlerKathleen van Leeuwen
Sep 3, 2009·Current Opinion in Obstetrics & Gynecology

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