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Complete blockade by phenoxybenzamine of alpha 1- but not of alpha 2-vascular receptors in dogs and the effects of propranolol

Naunyn-Schmiedeberg's Archives of Pharmacology

Nov 1, 1980

J W Constantine, W Lebel

PMID: 6256667

Abstract

In pithed dogs pressor responses to phenylephrine were completely inhibited 1 h after phenoxybenzamine 20 mg/kg i.v., but those to norepinephrine were only partially inhibited. The pressor effects of norepinephrine in phenoxybenzamine-treated animals were inhibited by yohimbine, 2.0 mg/...read more

Mentioned in this Paper

Phenylephrine Hydrochloride
Yohimbin Spiegel
Phenoxybenzamine Hydrochloride
Diastolic Blood Pressure
Medihaler-Epi
Norepinephrine Receptors
Rexigen
Pratsiol
Alpha-adrenergic receptor
Canis familiaris
Paper Details
References
  • References17
  • Citations35
12
  • References17
  • Citations35
1234

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alpha 1- and alpha 2-vascular adrenoceptors in the dog

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J W ConstantineR A Weeks
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Complete blockade by phenoxybenzamine of alpha 1- but not of alpha 2-vascular receptors in dogs and the effects of propranolol

Naunyn-Schmiedeberg's Archives of Pharmacology

Nov 1, 1980

J W Constantine, W Lebel

PMID: 6256667

DOI:

Abstract

In pithed dogs pressor responses to phenylephrine were completely inhibited 1 h after phenoxybenzamine 20 mg/kg i.v., but those to norepinephrine were only partially inhibited. The pressor effects of norepinephrine in phenoxybenzamine-treated animals were inhibited by yohimbine, 2.0 mg/...read more

Mentioned in this Paper

Phenylephrine Hydrochloride
Yohimbin Spiegel
Phenoxybenzamine Hydrochloride
Diastolic Blood Pressure
Medihaler-Epi
Norepinephrine Receptors
Rexigen
Pratsiol
Alpha-adrenergic receptor
Canis familiaris

Similar Papers Found In These Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Related Papers

European Journal of Pharmacology

alpha 1- and alpha 2-vascular adrenoceptors in the dog

European Journal of PharmacologySeptember 5, 1980
J W ConstantineR A Weeks
Paper Details
References
  • References17
  • Citations35
12
  • References17
  • Citations35
1234
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