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Complete blockade by phenoxybenzamine of alpha 1- but not of alpha 2-vascular receptors in dogs and the effects of propranolol

Naunyn-Schmiedeberg's Archives of Pharmacology

Nov 1, 1980

J W Constantine, W S Lebel

PMID: 6256667

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Abstract

In pithed dogs pressor responses to phenylephrine were completely inhibited 1 h after phenoxybenzamine 20 mg/kg i.v., but those to norepinephrine were only partially inhibited. The pressor effects of norepinephrine in phenoxybenzamine-treated animals were inhibited by yohimbine, 2.0 mg/...read more

Mentioned in this Paper

Canis familiaris
Phenylephrine Hydrochloride
Yohimbin Spiegel
Pratsiol
Rexigen
Norepinephrine Receptors
Phenoxybenzamine Hydrochloride
Alpha-adrenergic receptor
Medihaler-Epi
Diastolic Blood Pressure
Paper Details
References
    • References16
    • Citations34
    • References16
    • Citations34
  • Complete blockade by phenoxybenzamine of alpha 1- but not of alpha 2-vascular receptors in dogs and the effects of propranolol

    Naunyn-Schmiedeberg's Archives of Pharmacology

    Nov 1, 1980

    J W Constantine, W S Lebel

    PMID: 6256667

    DOI:

    Abstract

    In pithed dogs pressor responses to phenylephrine were completely inhibited 1 h after phenoxybenzamine 20 mg/kg i.v., but those to norepinephrine were only partially inhibited. The pressor effects of norepinephrine in phenoxybenzamine-treated animals were inhibited by yohimbine, 2.0 mg/...read more

    Mentioned in this Paper

    Canis familiaris
    Phenylephrine Hydrochloride
    Yohimbin Spiegel
    Pratsiol
    Rexigen

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    Paper Details
    References
    • References16
    • Citations34
    • References16
    • Citations34
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