Complete blood count reference intervals for healthy Han Chinese adults

PloS One
Xinzhong WuHong Shang

Abstract

Complete blood count (CBC) reference intervals are important to diagnose diseases, screen blood donors, and assess overall health. However, current reference intervals established by older instruments and technologies and those from American and European populations are not suitable for Chinese samples due to ethnic, dietary, and lifestyle differences. The aim of this multicenter collaborative study was to establish CBC reference intervals for healthy Han Chinese adults. A total of 4,642 healthy individuals (2,136 males and 2,506 females) were recruited from six clinical centers in China (Shenyang, Beijing, Shanghai, Guangzhou, Chengdu, and Xi'an). Blood samples collected in K2EDTA anticoagulant tubes were analyzed. Analysis of variance was performed to determine differences in consensus intervals according to the use of data from the combined sample and selected samples. Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers. Red blood cell count (RBC), hemoglobin (HGB), and hematocrit (HCT) values were higher in males than in females at all ages. Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference. Thalassemia carriers were ...Continue Reading

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Citations

Dec 15, 2015·Medicine·Xuzhen QinKiyoshi Ichihara
Sep 19, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Eun Jin LeeYoung Kyung Lee
May 11, 2019·Annals of the New York Academy of Sciences·Josh M JorgensenKathryn G Dewey
Jul 2, 2019·Annals of the New York Academy of Sciences·Max GassmannMartina U Muckenthaler
Dec 4, 2020·International Journal of General Medicine·Dana Ahmed AbdullahHeshu Sulaiman Rahman
Oct 2, 2020·Journal of Applied Physiology·Heimo MairbäurlMartina U Muckenthaler
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Sep 4, 2020·International Journal of Laboratory Hematology·Abigail S A BawuaJulius Fobil
Jul 28, 2021·Scandinavian Journal of Clinical and Laboratory Investigation·Chandana Wickramaratne Kurukula Arachchi, Devika Champa Wijewickrama

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Methods Mentioned

BETA
blood collection
PCR

Software Mentioned

Statistical Package for Social Sciences ( SPSS
Excel

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