Complete cerebral ischemia with short-term survival in rats induced by cardiac arrest. I. Extracellular accumulation of Alzheimer's beta-amyloid protein precursor in the brain

Brain Research
R PlutaH M Wiśniewski

Abstract

The distribution of beta-amyloid protein precursor (APP) was investigated immunocytochemically in rats subjected to global cerebral ischemia (GCI) induced by cardiac arrest. Rats underwent 10 min of GCI with 3, 6, and 12 h and 2 and 7 days of survival. APP immunostaining was found extracellular and intracellularly. Multiple extracellular APP immunoreactive deposits around and close to the vessels appeared as soon as 3 h after GCI. Extracellular accumulation of APP occurred frequently in the hippocampus, cerebral and cerebellar cortex, basal ganglia and thalamus and rarely in the brain stem. These deposits were labelled with antibodies against the N-terminal, beta-amyloid peptide, and C-terminal domains of APP. Our data suggests that either proteolytically cleaved fragments of the full-length APP or the entire APP molecule accumulates extracellularly after GCI. This findings may not only implicate the participation of APP in postischemic tissue damage but also suggest the involvement of pathomechanisms operating in ischemia in Alzheimer's disease pathology.

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Citations

Sep 7, 2007·Acta Neuropathologica·John C Fiala
Jun 17, 2005·Journal of Neural Transmission·J SzczygielskiO Wirths
Nov 6, 2002·Journal of the Neurological Sciences·Ryszard Pluta
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Feb 19, 2011·Communicative & Integrative Biology·Francesca RubertiCarlo Cogoni
Mar 10, 2017·Experimental Neurology·Ashish K RehniKunjan R Dave
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May 6, 2020·International Journal of Molecular Sciences·Ryszard PlutaStanisław J Czuczwar
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Oct 7, 2016·Pharmacological Reports : PR·Marzena Ułamek-KoziołStanisław J Czuczwar
Feb 6, 2020·International Journal of Molecular Sciences·Marzena Ułamek-KoziołRyszard Pluta
Jan 18, 2020·International Journal of Molecular Sciences·Marzena Ułamek-KoziołRyszard Pluta
Oct 5, 2018·Journal of Alzheimer's Disease : JAD·Ryszard PlutaStanisław J Czuczwar
Mar 5, 2016·Pharmacological Reports : PR·Marzena Ułamek-KoziołStanisław J Czuczwar
Dec 14, 2018·International Journal of Molecular Sciences·Ryszard PlutaStanisław J Czuczwar
Jul 2, 2020·International Journal of Molecular Sciences·Ryszard PlutaStanisław J Czuczwar
Oct 31, 2020·Frontiers in Immunology·Mikhail InyushinLilia Kucheryavykh

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