PMID: 6886082Jul 1, 1983

Complete Freund's adjuvant-induced pneumonia in swine: a model of interstitial lung disease

Journal of Comparative Pathology
J F Edwards, D O Slauson


Intravenously administered complete Freund's adjuvant, emulsified in saline, induced a lesion in the porcine lung characterized by a disseminated histiocytic interstitial pneumonia, type II pneumocyte proliferation and granulomatous arteriolitis. In addition, there was a persistent increase in numbers of alveolar macrophages. The lesion was well developed in 7 days. The sequential development and early resolution of the light microscopic lesions was studied for a period of 21 days after inoculation. The administration of Freund's adjuvant induced a spectrum of lesions typical of many forms of interstitial lung diseases of man and domestic animals. The pig is a suitable host for the investigation of the pulmonary inflammatory response and the repair mechanisms involved in chronic lung disease produced by infectious agents or environmental antigens.


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Mar 1, 1981·The American Journal of Medicine·R G CrystalG W Hunninghake


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Related Concepts

Freund's Adjuvant
Experimental Lung Inflammation

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