PMID: 6886082Jul 1, 1983

Complete Freund's adjuvant-induced pneumonia in swine: a model of interstitial lung disease

Journal of Comparative Pathology
J F Edwards, D O Slauson

Abstract

Intravenously administered complete Freund's adjuvant, emulsified in saline, induced a lesion in the porcine lung characterized by a disseminated histiocytic interstitial pneumonia, type II pneumocyte proliferation and granulomatous arteriolitis. In addition, there was a persistent increase in numbers of alveolar macrophages. The lesion was well developed in 7 days. The sequential development and early resolution of the light microscopic lesions was studied for a period of 21 days after inoculation. The administration of Freund's adjuvant induced a spectrum of lesions typical of many forms of interstitial lung diseases of man and domestic animals. The pig is a suitable host for the investigation of the pulmonary inflammatory response and the repair mechanisms involved in chronic lung disease produced by infectious agents or environmental antigens.

References

Oct 7, 1975·Virchows Archiv. A, Pathological Anatomy and Histology·P SolerF Basset
Jan 1, 1979·Journal of Immunological Methods·A G HarmsenE L Jeska
Apr 1, 1978·The Journal of Pathology·R E BrooksR D Moore
Jan 1, 1973·The Journal of Pathology·G P Velo, W G Spector
Mar 1, 1981·The American Journal of Medicine·R G CrystalG W Hunninghake

Citations

Jan 1, 2004·Veterinary Immunology and Immunopathology·L MandrioliP S Marcato
Jan 1, 1984·Avian Pathology : Journal of the W.V.P.A·N A MehdiJ Tuite
Sep 19, 2015·Animal : an International Journal of Animal Bioscience·E LabussièreJ van Milgen
Feb 22, 2008·Journal of Veterinary Medical Education·Jon S PattersonMichael A Scott
Jan 22, 2015·The British Journal of Nutrition·Esther Kampman-van de HoekAlfons J M Jansman
Apr 15, 2004·Journal of Animal Science·D MelchiorN Le Floc'h

Related Concepts

Freund's Adjuvant
Lung
Macrophage
Experimental Lung Inflammation

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