The Small Cabbage White ( Pieris rapae) is originally a Eurasian butterfly. Being accidentally introduced into North America, Australia, and New Zealand a century or more ago, it spread throughout the continents and rapidly established as one of the most abundant butterfly species. Although it is a serious pest of cabbage and other mustard family plants with its caterpillars reducing crops to stems, it is also a source of pierisin, a protein unique to the Whites that shows cytotoxicity to cancer cells. To better understand the unusual biology of this omnipresent agriculturally and medically important butterfly, we sequenced and annotated the complete genome from USA specimens. At 246 Mbp, it is among the smallest Lepidoptera genomes reported to date. While 1.5% positions in the genome are heterozygous, they are distributed highly non-randomly along the scaffolds, and nearly 20% of longer than 1000 base-pair segments are SNP-free (median length: 38000 bp). Computational simulations of population evolutionary history suggest that American populations started from a very small number of introduced individuals, possibly a single fertilized female, which is in agreement with historical literature. Comparison to other Lepidoptera gen...Continue Reading
Cytotoxic activity of pierisin, from the cabbage butterfly, Pieris rapae, in various human cancer cell lines
Molecular cloning of an apoptosis-inducing protein, pierisin, from cabbage butterfly: possible involvement of ADP-ribosylation in its activity
Purification and cloning of pierisin-2, an apoptosis-inducing protein from the cabbage butterfly, Pieris brassicae
Mono(ADP-ribosyl)ation of 2'-deoxyguanosine residue in DNA by an apoptosis-inducing protein, pierisin-1, from cabbage butterfly
Identification of glycosphingolipid receptors for pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly.
Gene prediction in eukaryotes with a generalized hidden Markov model that uses hints from external sources
Comparative biochemical characterization of nitrile-forming proteins from plants and insects that alter myrosinase-catalysed hydrolysis of glucosinolates
Automated eukaryotic gene structure annotation using EVidenceModeler and the Program to Assemble Spliced Alignments
The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data
Cell-free synthesis and characterization of a novel cytotoxic pierisin-like protein from the cabbage butterfly Pieris rapae
TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
Demonstration of cytotoxicity against wasps by pierisin-1: a possible defense factor in the cabbage white butterfly
De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis
The novel structure of the cockroach allergen Bla g 1 has implications for allergenicity and exposure assessment.
Identification of putative cytochrome P450 monooxygenase genes from the small white butterfly, Pieris rapae (Lepidoptera: Pieridae), and their response to insecticides
Gene expression profiling across ontogenetic stages in the wood white (Leptidea sinapis) reveals pathways linked to butterfly diapause regulation
Rapid Increase in Genome Size as a Consequence of Transposable Element Hyperactivity in Wood-White (Leptidea) Butterflies
Compound eyes of the small white butterfly Pieris rapae have three distinct classes of red photoreceptors
Global invasion history of the agricultural pest butterfly Pieris rapae revealed with genomics and citizen science
Chromosomal-level reference genome of Chinese peacock butterfly (Papilio bianor) based on third-generation DNA sequencing and Hi-C analysis
Identification and Expression Profiles of 14 Odorant-Binding Protein Genes From Pieris rapae (Lepidoptera: Pieridae)
Unprecedented reorganization of holocentric chromosomes provides insights into the enigma of lepidopteran chromosome evolution
Genome of the webworm Hyphantria cunea unveils genetic adaptations supporting its rapid invasion and spread
Multi-faceted analysis provides little evidence for recurrent whole-genome duplications during hexapod evolution.
Mitogenomes of Giant-Skipper Butterflies reveal an ancient split between deep and shallow root feeders
Molecular Characterization and Expression Analysis of Two Acetylcholinesterase Genes From the Small White Butterfly Pieris rapae (Lepidoptera: Pieridae)
Dissecting the Effects of Selection and Mutation on Genetic Diversity in Three Wood White (Leptidea) Butterfly Species
Chromosome-level reference genome assembly and gene editing of the dead-leaf butterfly Kallima inachus.
Characterisation of a copper/zinc superoxide dismutase from Pieris rapae and its role in protecting against oxidative stress induced by chlorantraniliprole.
Spatial phylogenetics of butterflies in relation to environmental drivers and angiosperm diversity across North America.
Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis
Apoptosis in Cancer
Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.