Complete genome sequence and comparative genome analysis of the Paenibacillus mucilaginosus K02

Microbial Pathogenesis
Bo XiaoTian-Ming Chen

Abstract

Paenibacillus mucilaginosus (P. mucilaginosus) K02 is implicated in mineral weathering. However, relevant molecular mechanisms remain obscure. The study aims to uncover the bacterium's physiological processes using genomic approaches. Genomic DNA from P. mucilaginosus K02 was sequenced using high-throughput Solexa sequencing technology and then conducted for Clusters of Orthologous Group (COG) annotation. Thereafter, genome sequences of K02 were compared with two strains, 3016 and KNP414. Mummer was applied for collinearity analysis of three P. mucilaginosus genomes. BLAST was used to identify pan and core genes in these strains. Finally, a phylogenetic tree was constructed using the maximum likelihood method by TreeBeST. Complete genome sequence of P. mucilaginosus K02 indicated the strain comprises one circular chromosome with 8,819,200 bases containing 58.3% GC content and 84.75% coding regions. A total of 7299 predicted ORFs were identified in the genome, among them, several genes were related to carbonic anhydrase (CA), and exopolysaccharide biosynthesis and secretion. Moreover, proteins of the predicted genes were annotated in COG categories such as "Carbohydrate transport and metabolism" and "Inorganic ion transport and ...Continue Reading

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Citations

Jun 15, 2013·Trends in Microbiology·Emilie E L MullerPaul Wilmes
Dec 3, 2016·Microbial Cell Factories·Elliot Nicholas GradyZe-Chun Yuan
Jan 11, 2017·International Journal of Genomics·Huihui DuZeyang Zhou
Aug 30, 2017·Frontiers in Microbiology·Yue-Hui HongJiang-Hai Wang

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