Complete genomic sequence of a border disease virus isolated from Pyrenean chamois

Virus Research
S VilcekP Becher

Abstract

This report describes the full-length genome sequence of the pestivirus strain H2121 which was recently isolated from Pyrenean chamois and typed as Border disease virus (BDV) genotype 4. Comparison with full-length genomic sequences of the approved pestivirus species Bovine viral diarrhea virus-1 (BVDV-1), BVDV-2, BDV, and Classical swine fever virus, the tentative species represented by strain Giraffe-1, as well as the atypical pestivirus strain Th/04_KhonKaen confirmed that the chamois pestivirus strain is most similar to BDV. The viral genome of H2121 is 12,305 nucleotides long and contains one large open reading frame. The latter encodes a polyprotein consisting of 3899 amino acids and is flanked with 376 nucleotides long 5' untranslated region (UTR) and 229 nt long 3' UTR. The genome organization of the chamois virus is reminiscent to that of other pestiviruses. Compared to other BDV strains including BDV-1 strain X818 and BDV-2 strain Reindeer-1, the 5' UTR and ORF of the chamois virus are very similar in length, while the 3' UTR of H2121 is 31-44 nucleotides shorter. In contrast to other BDV strains, the genome of the chamois virus contains a unique four amino acid insertion at the N-terminus of NS2.

References

Jun 1, 1996·Journal of Virological Methods·S Vilcek, S Belák
Apr 1, 1997·The Journal of General Virology·S VilcekS Belák
Jun 1, 1997·The Journal of General Virology·P BecherH J Thiel
Aug 4, 2001·Virology·R Avalos-RamirezP Becher
Dec 4, 2004·Archives of Virology·F ThabtiP Russo
Aug 24, 2005·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·G M De MiaA De Giuseppe
Oct 11, 2005·Preventive Veterinary Medicine·H P StalderE Peterhans
Jul 15, 2006·Veterinary Microbiology·S Vilcek, P F Nettleton
Nov 10, 2006·Veterinary Microbiology·Maryline PiozEmmanuelle Gilot-Fromont
Nov 28, 2006·The Veterinary Journal·B Valdazo-GonzálezT Sandvik
Aug 19, 2007·The Veterinary Record·M P CranwellT Sandvik
Feb 27, 2008·Veterinary Microbiology·Eric DuboisRichard Thiéry
Nov 21, 2008·Veterinary Microbiology·T C OguzogluI Greiser-Wilke
Jan 27, 2009·Virology·Lihong LiuClaudia Baule
Oct 24, 2009·Virus Research·Lihong LiuNiklas Wahlberg

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