Complete genomic sequences of Propionibacterium freudenreichii phages from Swiss cheese reveal greater diversity than Cutibacterium (formerly Propionibacterium) acnes phages

BMC Microbiology
Lucy ChengRobert L Modlin

Abstract

A remarkable exception to the large genetic diversity often observed for bacteriophages infecting a specific bacterial host was found for the Cutibacterium acnes (formerly Propionibacterium acnes) phages, which are highly homogeneous. Phages infecting the related species, which is also a member of the Propionibacteriaceae family, Propionibacterium freudenreichii, a bacterium used in production of Swiss-type cheeses, have also been described and are common contaminants of the cheese manufacturing process. However, little is known about their genetic composition and diversity. We obtained seven independently isolated bacteriophages that infect P. freudenreichii from Swiss-type cheese samples, and determined their complete genome sequences. These data revealed that all seven phage isolates are of similar genomic length and GC% content, but their genomes are highly diverse, including genes encoding the capsid, tape measure, and tail proteins. In contrast to C. acnes phages, all P. freudenreichii phage genomes encode a putative integrase protein, suggesting they are capable of lysogenic growth. This is supported by the finding of related prophages in some P. freudenreichii strains. The seven phages could further be distinguished as ...Continue Reading

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Citations

Jun 9, 2020·Environmental Microbiology·Alessandra G de MeloSylvain Moineau
Sep 30, 2020·Annual Review of Virology·Graham F Hatfull
Jun 20, 2020·PloS One·Deborah Jacobs-SeraGraham F Hatfull
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Apr 21, 2021·Food Microbiology·Bruna Leal MaskeCarlos Ricardo Soccol

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Datasets Mentioned

BETA
CCYX01000001

Software Mentioned

Newbler Assembler Consed
BLASTN
ABySS
Gepard
Phamerator
SplitsTree
CRISPRfinder

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