Complete nucleotide sequence of a type 4 hepatitis C virus variant, the predominant genotype in the Middle East

The Journal of General Virology
R W ChamberlainR M Elliott

Abstract

Hepatitis C virus (HCV) type 4 is the predominant genotype found throughout the Middle East and parts of Africa, often in association with high population prevalence as in Egypt. To investigate more fully its evolutionary relationship with other genotypes of HCV, and to study its overall genome organization, we have determined the entire sequence encompassing the coding region of the genotype 4a isolate ED43, obtained from an HCV-infected individual from Egypt. The sequence of ED43 contained a single open reading frame encoding a polyprotein of 3008 amino acids (aa), smaller than that reported for other HCV genotypes which vary from 3010 aa to 3037 aa. The nucleotide and amino acid sequences were compared with the full-length sequences already reported for genotypes 1a, 1b, 1c, 2a, 2b, 2c, 3a, 3b and those of isolates JKO49 and JKO46 described as types 10a and 11a. The differences in length of the polyprotein originated in variable regions in the E2 and NS5A genes. The complete sequence of ED43 confirmed the classification of type 4 as a separate major genotype.

Citations

Nov 12, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sam LattimoreUNKNOWN Collaboration for the Sentinel Surveillance of Blood-Borne Virus Testing
Mar 4, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Anchalee Sistayanarain, Suriya Chaiwong
May 5, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sadia ButtShazia Rafique
Aug 21, 2013·Journal of Medical Virology·Sanja KiprijanovskaDijana Plaseska-Karanfilska
Apr 22, 2009·Journal of Medical Virology·Paola PizzilloRosa Di Stefano
Apr 10, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Rita Raafat GadGamal Esmat
Feb 2, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sanaa M Kamal, Imad A Nasser
Dec 7, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Tatsunori NakanoMasashi Mizokami
Feb 15, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Philip MeulemanGeert Leroux-Roels
Oct 12, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Donald B SmithPeter Simmonds
Jul 19, 2005·Clinics in Liver Disease·Mindie H Nguyen, Emmet B Keeffe
Sep 15, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Magnus Lindh, Charles Hannoun
Aug 6, 2014·Hepatitis Research and Treatment·Shamim SalehaSanaullah Khan
Mar 28, 2006·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·S Ramia, J Eid-Fares
Aug 25, 2009·Virology Journal·Muhammad IdreesSheikh Riazuddin
Apr 1, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C M OlingerC P Muller
Mar 30, 2004·Biochemical and Biophysical Research Communications·Wan-Fen KuangLih-Hwa Hwang
Jun 11, 2011·International Journal of Nephrology·Osama Ashry Ahmed Gheith
May 15, 1998·Journal of Medical Virology·M Leruez-VilleP Dény
Dec 27, 2011·Transactions of the Royal Society of Tropical Medicine and Hygiene·Sayed AbdelwahabG Thomas Strickland
Jan 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Troels K H ScheelJens Bukh
Mar 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jean-Christophe MeunierJens Bukh
May 28, 2014·Revista Da Sociedade Brasileira De Medicina Tropical·Isaura Cunha MeloIvonete Sandra de Souza e Silva
Sep 9, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Peter SimmondsAnders Widell
Jul 1, 2005·Parasite Immunology·A FaridG T Strickland
Mar 24, 2006·Journal of Medical Virology·Seyed Mohammadmehdi Hosseini-MoghaddamSeyed-Moayed Alavian
Jun 2, 2007·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Madhavi ChandraMohammed N Khaja

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