PMID: 6406897May 26, 1983Paper

Complete nucleotide sequence of an immunoglobulin VH gene homologue from Caiman, a phylogenetically ancient reptile

Nature
Gary W LitmanB W Erickson

Abstract

Immunoglobulin variable (V) gene regions typify extensive multigenic families in terms of overall size, chromosomal arrangement and presence of large numbers of apparent pseudogenes. A unique mechanism of somatic reorganization involving recombination of VH, D and JH or VL and JL segments accompanies the differentiation of lymphoid cells and together with somatic mutation and other types of recombination accounts for V-region diversity. Although these processes have been well characterized in higher mammals, little is known concerning their origin and diversification during phylogenetic time. Previously, we described the blot-hybridization characteristics of murine VHIII probes with restriction enzyme-digested genomic DNA isolated from several phylogenetically critical species, including Caiman crocodylus, a modern representative of an ancient reptilian subclass. Here we have used a murine probe, S107V, to select homologous clones from a library of Caiman genomic DNA constructed in a lambda bacteriophage. The complete nucleotide sequence of a Caiman gene homologous to the murine VH gene and its adjacent 5' and 3' region is described. Comparison of the sequence with mammalian prototypes shows evidence of considerable organizatio...Continue Reading

References

Oct 6, 1978·Science·J G SeidmanP Leder
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·T T WuH Bilofsky
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D J KempJ M Adams
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·T T WuH Bilofsky
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·D M SegalD R Davies
Jan 1, 1980·Methods in Enzymology·A M Maxam, W Gilbert
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J KarnG Cesareni
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·F W Alt, D Baltimore
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M W ShawP W Choppin
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·G Matthyssens, T H Rabbitts
Jul 30, 1981·Nature·D GivolJ B Cohen
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G RechaviD Givol
May 28, 1982·Molecular and Cellular Biochemistry·G W LitmanO Mäkelä

❮ Previous
Next ❯

Citations

Jan 1, 1984·Developmental and Comparative Immunology·G W LitmanB W Erickson
Jan 1, 1985·Developmental and Comparative Immunology·T Matsunaga
Dec 1, 1987·Veterinary Immunology and Immunopathology·P A Lalor, L A Herzenberg
May 1, 1996·Research in Immunology·E Andersson, T Matsunaga
Jan 1, 1986·Bulletin of Mathematical Biology·S F Altschul, B W Erickson
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·G W LitmanB W Erickson
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S OhnoT Matsunaga
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A Tutter, R Riblet
Jul 11, 1984·Nucleic Acids Research·M E Watson
May 20, 2008·Molecular Immunology·Francisco Gambón-Deza, Christian Sánchez Espinel
Nov 7, 2006·Developmental and Comparative Immunology·Francisco Gambón DezaJulio Valdueza Beneitez
Jun 15, 1987·Biochemical and Biophysical Research Communications·S F SchluterJ J Marchalonis
May 4, 1992·Annals of the New York Academy of Sciences·G W LitmanM Hulst
Feb 25, 1984·Journal of Molecular Biology·G von Heijne

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.