PMID: 9188619Jul 1, 1997Paper

Complete nucleotide sequence of the new simian T-lymphotropic virus, STLV-PH969 from a Hamadryas baboon, and unusual features of its long terminal repeat

Journal of Virology
M Van BrusselA M Vandamme

Abstract

A third type of primate T-lymphotropic virus, PTLV-L, with STLV-PH969 as a prototype, has recently been isolated from an African baboon (Papio hamadryas). Classification of this virus has been based on partial sequence analysis of cDNA from a virus-producing cell line, PH969. We obtained the complete nucleotide sequence of this virus with a proviral genome of 8,916 bp. All major genes, homologous in all human T-cell lymphotropic virus (HTLV)-related viruses, and their corresponding mRNAs, including appropriate splicing, were identified. One additional nonhomologous open reading frame in the proximal pX region is accessible for translation through alternative splicing. Sequence comparison shows that STLV-PH969 is equidistantly related to HTLV type 1 (HTLV-1) and HTLV-2. In all coding regions, the similarity tends to be the lowest between STLV-PH969 and HTLV-1. However, in the long terminal repeat (LTR) region, the lowest similarity was found between STLV-PH969 and HTLV-2. The U3-R and R-U5 boundaries of the STLV-PH969 LTR were experimentally determined at nucleotides 268 and 524, respectively. This 695-bp LTR is 60 and 73 bp shorter than the LTRs of HTLV-1 and HTLV-2, respectively, but its general organization is similar to the ...Continue Reading

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Citations

Jul 10, 2004·AIDS Research and Human Retroviruses·Maria MakuwaPierre Roques
Apr 18, 2008·Journal of Virology·Sébastien Alain ChevalierRenaud Mahieux
Feb 3, 1999·Annals of the New York Academy of Sciences·J S Allan
Dec 23, 2008·The Journal of Infectious Diseases·Sara CalattiniAntoine Gessain
Jan 19, 2002·Journal of Virology·Taichiro TakemuraMasanori Hayami

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