Complete pathological response to transcatheter arterial infusion despite a rapidly progressing recurrent hepatocellular carcinoma with portal vein tumor thrombus: A case report

International Journal of Surgery Case Reports
Masanobu TaguchiYoshikazu Yasuda

Abstract

We report a patient with a rapidly progressing recurrence of hepatocellular carcinoma (HCC) with a portal vein tumor thrombus after radiofrequency ablation of the original lesion, then treated with transcatheter arterial infusion. Radical hepatic resection demonstrated a complete pathological response. A 60-year old male with alcoholic cirrhosis and gastric varices was diagnosed with HCC measuring 12mm in segment 8. He underwent laparoscopic radiofrequency ablation, but recurred three months later. The lesion progressed rapidly and the right portal vein was occluded. He then underwent transcatheter arterial infusion with miriplatin and iodized oil, which was effective in reducing the size of the main lesion and portal vein tumor thrombus. Right anterior sectionectomy was then performed. Pathologically, there were no viable HCC cells in either the main lesion or the portal vein thrombus. He is alive two years and nine months after surgery without recurrence. A rapidly progressing HCC recurrence with portal vein tumor thrombus is usually associated with a poor prognosis. No effective treatments have been reported in this situation except hepatic resection. In this patient the tumor was effectively reduced after three courses of t...Continue Reading

References

Oct 31, 2003·International Journal of Clinical Oncology·Yasutsugu TakadaNobuhiro Ohkohchi
Apr 8, 2004·World Journal of Gastroenterology : WJG·Andrea RuzzenenteAlfredo Guglielmi
Jul 14, 2004·American Journal of Surgery·Nicola NicoliGiancarlo Mansueto
Dec 24, 2005·Journal of Vascular and Interventional Radiology : JVIR·Christos S GeorgiadesJean-Francois H Geschwind
Jun 14, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Y Patrice Le TreutPierre Campan

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BETA
biopsy
surgical resection

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