PMID: 8601855Mar 1, 1996Paper

Complete recovery after normothermic hemorrhagic shock and profound hypothermic circulatory arrest of 60 minutes in dogs

The Journal of Trauma
A CaponeS Tisherman

Abstract

We hypothesize that during severe normothermic hemorrhagic shock (HS), induction of profound hypothermic circulatory arrest (PHCA) of 60 minutes to allow repair of otherwise lethal injuries in a bloodless field, can be survived without brain damage. In previous dog studies, normothermic HS with mean arterial pressure (MAP) of 40 mm Hg for 30 minutes, followed by PHCA of 2 hours at brain (tympanic membrane) temperature of 5 to 10 degrees C and core temperature of 10 degrees C, induced and reversed with cardiopulmonary bypass, resulted in survival with mild histopathologic brain damage. This study was designed to determine the severity of HS that can safely allow 1 hour of PHCA. In pilot studies with HS at MAP 30 mm Hg for 90 minutes with or without subsequent PHCA of 60 minutes there were no survivors. In the definitive study, outcomes in four groups of five dogs each were compared: group I, HS at MAP 30 mm Hg for 60 minutes and normothermic fluid resuscitation; group II, HS at MAP 30 mm Hg for 60 minutes, PHCA for 60 minutes, and resuscitation; group III, HS at MAP 40 mm Hg for 60 minutes and normothermic fluid resuscitation; and group IV, HS at MAP 40 mm Hg for 60 minutes, PHCA for 60 minutes, and resuscitation. Controlled ven...Continue Reading

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Citations

Jan 8, 2000·The Surgical Clinics of North America·S A TishermanP Safar
Apr 10, 2002·Critical Care Medicine·Peter SafarFritz Sterz
Mar 27, 2004·Critical Care Medicine·Samuel A Tisherman
Jan 26, 2007·Critical Care Medicine·Hasan B Alam
Jun 26, 2009·Critical Care Medicine·Eugene Y Fukudome, Hasan B Alam
Apr 1, 1997·Acta Anaesthesiologica Scandinavica·A Yli-HankalaP Y Zhang
Dec 2, 2000·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·W BehringerS A Tisherman
Jul 14, 2000·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·P Safar
May 25, 2006·Acute Cardiac Care·Fritz SterzMichael Holzer
Jul 2, 2011·Current Problems in Surgery·Hasan B Alam, George C Velmahos
Jan 5, 2002·The Surgical Clinics of North America·M OrlinskyM D Kerstein
Aug 3, 2012·Journal of Veterinary Emergency and Critical Care·Sean D SmarickUNKNOWN RECOVER Post-Cardiac Arrest Care Domain Worksheet Authors
Oct 27, 2015·International Journal of Surgery·Matthew E KutcherSamuel A Tisherman
Jan 25, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wilhelm BehringerSamuel A Tisherman
May 7, 2010·Journal of Intensive Care Medicine·Robert A Finkelstein, Hasan B Alam
May 26, 2017·The Journal of Trauma and Acute Care Surgery·Samuel A TishermanPatrick M Kochanek
Nov 19, 2017·ANZ Journal of Surgery·Syed MohiyaddinSaeed Ashraf
May 13, 2017·Journal of the Royal Army Medical Corps·Samuel E MoffattJ L Walke
Oct 3, 2012·The Journal of Trauma and Acute Care Surgery·Hasan B AlamUNKNOWN HYPOSTAT workshop participants
Oct 5, 2006·Current Opinion in Anaesthesiology·Peter J Safar, Samuel A Tisherman
Dec 24, 2004·Current Opinion in Critical Care·Samuel A Tisherman
Oct 26, 2013·The Journal of Trauma and Acute Care Surgery·Philippe BidermanBenjamin Medalion
Nov 28, 2002·Current Opinion in Critical Care·Joost J L M BierensHarry P M M Gelissen
Oct 28, 2006·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·H B Alam

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