Complete Regrowth of Beard Hair with Ruxolitinib in an Alopecia Universalis Patient

Skin Appendage Disorders
Yuval Ramot, Abraham Zlotogorski

Abstract

While most alopecia areata (AA) cases resolve spontaneously, the more severe types of AA, alopecia totalis (AT) and alopecia universalis (AU), can be highly resistant to therapy. We report on a 33-year-old ultraorthodox Jewish man with an 11-year history of AA that resulted in complete loss of the scalp and body hair 7 years ago. Previous treatments with intralesional and systemic corticosteroids had only partial and temporary effects. The patient was treated with ruxolitinib, 20 mg twice daily, resulting in complete growth of the beard after 4 months of treatment. The beard has a special significance for ultraorthodox Jews, and loss of the beard hair can have marked social and psychological consequences in AA patients. The Janus kinase (JAK) inhibitors have recently emerged as an effective treatment modality in AA, including the more severe forms, such as AT or AU. This report highlights the beneficial effects of the JAK inhibitors, especially in populations where the hair has a special importance due to cultural and religious backgrounds.

References

Oct 22, 2005·BMJ : British Medical Journal·Nigel Hunt, Sue McHale
Jan 9, 2009·Journal of Health Psychology·Patricia Tucker
Aug 13, 2014·International Journal of Trichology·Taciana Rocha de HollandaMarcia Ramos-E-Silva
Feb 14, 2015·Journal of Dermatological Science·Roni BiranYuval Ramot
Jul 3, 2015·EBioMedicine·Ali JabbariAbraham Zlotogorski
Dec 22, 2015·Journal of the American Academy of Dermatology·John E HarrisJulian Mackay-Wiggan
Jan 19, 2016·Journal of the American Academy of Dermatology·Rony Shreberk-HassidimAbraham Zlotogorski
May 11, 2016·Expert Opinion on Biological Therapy·Yael Renert-Yuval, Emma Guttman-Yassky
Aug 10, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·D Saceda-CorraloS Vañó-Galván
Nov 7, 2016·Journal of the American Academy of Dermatology·Lucy Y LiuBrett A King
Feb 9, 2017·Journal of the American Academy of Dermatology·Rony Shreberk-HassidimAbraham Zlotogorski
Mar 23, 2017·International Journal of Dermatology·Amy VandiverLuis A Garza
May 31, 2017·American Journal of Clinical Dermatology·Jessica CervantesAntonella Tosti

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Citations

Jan 16, 2019·Expert Opinion on Investigational Drugs·Jorge Ocampo-GarzaAntonella Tosti
Jan 29, 2019·Journal of Cutaneous Medicine and Surgery·Erika L CrowleyMelinda J Gooderham
Feb 15, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·K Phan, D F Sebaratnam
Aug 6, 2019·Dermatologic Therapy·Ana B de OliveiraJoão Maia-Silva
Jun 10, 2020·The Journal of Dermatological Treatment·Jessica Wu, Jan Smogorzewski
Dec 24, 2019·Expert Review of Clinical Pharmacology·Fathima Ferial Ismail, Rodney Sinclair
Jan 15, 2021·Dermatitis : Contact, Atopic, Occupational, Drug·Kyle TegtmeyerPeter A Lio
Jul 3, 2021·Clinical, Cosmetic and Investigational Dermatology·Kerry-Ann L Dillon
Dec 6, 2021·The Journal of Allergy and Clinical Immunology·Emma Guttman-YasskyElena Peeva
Jan 9, 2022·Dermatologic Therapy·Sarah BentonMaria Hordinsky

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