Complete remission of Cushing's disease by total bilateral adrenalectomy and adrenal autotransplantation

The Journal of Clinical Endocrinology and Metabolism
D BarzilaiA Schramek

Abstract

A 15-yr-old girl was diagnosed as suffering from Cushing's disease. She was treated by bilateral adrenalectomy and autotransplantation of one third of each adrenal to the corresponding thigh. The adrenal that was embedded in the right satorius muscle started functioning after about 1 yr, as proven by significant differences in cortisol levels in both femoral veins (82.5 and 17.5 micrograms/100 ml). 19-[131I]Cholesterol scanning showed adrenal tissue in the right thigh, while no adrenal remnant was demonstrated. Eleven years after surgery, the patient is symptom free and does not require replacement therapy. We find that adrenal autotransplantation, which is a simple and nonrisky procedure, should be considered whenever bilateral adrenalectomy is chosen as a treatment for Cushing's disease.

Citations

Aug 1, 1986·World Journal of Surgery·R G WatsonD M Ilstrup
Jan 1, 1982·Acta paediatrica Scandinavica·C G Bergstrand, K O Nilsson
Dec 5, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E GrodsteinM J Goldstein
Oct 1, 1982·The Journal of Urology·P J ChristensonK J O'Connell
May 1, 1993·The Journal of Urology·A M LuconS Arap

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