Complete remission of hepatitis B virus-related membranous nephropathy after entecavir monotherapy

Clinics and Research in Hepatology and Gastroenterology
Yong-Feng YangYan-Dan Zhong

Abstract

We reported a case of Hepatitis B virus-related membranous nephropathy (HBV-MN) with improvement under an ongoing 4.5-year of entecavir monotherapy. A 37 years old man with a 5 years' history of chronic hepatitis B (CHB) who was taken to our department because of proteinuria and microscopic haematuria. A renal biopsy led to a diagnosis of HBV-MN with mesangioproliferative. Interferon-alpha 2b (IFN-α2b) was stopped after 24 weeks due to the increasement of HBV-DNA and sustained HBeAg positive. Therefore, we started using 0.5mg entecavir per day. After 2 months' treatment, HBV-DNA was not detected in the blood, and the ALT and AST decreased to normal degree. After 3 years of entecavir therapy, virological tests revealed HBeAg seroconversion. With no further intervention during the next one and a half years, there was improvement of proteinuria gradually. This suggested that entecavir monotherapy may induce and maintain complete remission of membranous nephropathy associated with hepatitis B.

References

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Citations

Jan 26, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lifen WangWei Shi
Nov 6, 2013·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Toru IgarashiYasuhiko Itoh
Apr 24, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Cesare MazzaroGabriele Pozzato
Nov 12, 2014·European Journal of Gastroenterology & Hepatology·Dan LiGuoqing Zang
Jan 18, 2020·Expert Review of Gastroenterology & Hepatology·Yanjun LiuGuangming Li
Oct 16, 2020·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Lifen WangZhiming Ye

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